Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro

In our quest with respect to proposing alternative medicinal source against the global threat diabetes mellitus, a weed i.e. Mimosa pudica has been studied for its anti-diabetic potential. This study aimed to investigate in vitro inhibitory activity against diabetic enzymes (i.e. α-amylase & α-g...

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Main Authors:	Tunna, Tasnuva Sarwar, Sarker, Md. Zaidul Islam, Ahmed, Qamar Uddin, Md. Jaffri, Juliana
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/40672/ http://irep.iium.edu.my/40672/1/turning_weeds.pdf

id	iium-40672
recordtype	eprints
spelling	iium-406722015-03-03T02:02:10Z http://irep.iium.edu.my/40672/ Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro Tunna, Tasnuva Sarwar Sarker, Md. Zaidul Islam Ahmed, Qamar Uddin Md. Jaffri, Juliana RS Pharmacy and materia medica In our quest with respect to proposing alternative medicinal source against the global threat diabetes mellitus, a weed i.e. Mimosa pudica has been studied for its anti-diabetic potential. This study aimed to investigate in vitro inhibitory activity against diabetic enzymes (i.e. α-amylase & α-glucosidase) to evaluate potency of the weed against diabetes mellitus as well as to perform thorough chemical profiling using GCMS-Q-TOF, both done for first time for this weed, to assess the probable compounds present that could be linked to antidiabetic activity. Total phenolic and flavonoid contents along with DPPH radical scavenging assays were also done on five different extracts and fractions of M. pudica. Chemical class identification followed by derivetisation of the samples to analyse through GCMS was also done. Results showed good inhibitory activity against both the enzymes as compared to standard i.e. acarbose. At 1mg/mL, the MeOHi and EtOAc extracts showed two and three fold higher activity then the standard, respectively. Chemical profiling of all the extracts through GCMS- Q-TOF analysis identified organic acids, quinolone, quinone, phenolic compounds and dodecaborane as major constituents. Presence of highly radical scavenging dodecaborane is being reported for the 1st time in M. pudica. This study revealed that extracts of M. pudica is a rich source of phenolic compounds, dodecaborane, and organic acids and showed considerable high enzyme inhibitory activity. Extracts of M. pudica could be further subjected to isolation to identify the active principles responsible for its antidiabetic activity. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/40672/1/turning_weeds.pdf Tunna, Tasnuva Sarwar and Sarker, Md. Zaidul Islam and Ahmed, Qamar Uddin and Md. Jaffri, Juliana (2014) Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro. In: 1st International Conference on Industrial Pharmacy (ICIP) 2014, 16th-17th August 2014, Swiss Garden Resort & Spa, Kuantan, Pahang, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Tunna, Tasnuva Sarwar Sarker, Md. Zaidul Islam Ahmed, Qamar Uddin Md. Jaffri, Juliana Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
description	In our quest with respect to proposing alternative medicinal source against the global threat diabetes mellitus, a weed i.e. Mimosa pudica has been studied for its anti-diabetic potential. This study aimed to investigate in vitro inhibitory activity against diabetic enzymes (i.e. α-amylase & α-glucosidase) to evaluate potency of the weed against diabetes mellitus as well as to perform thorough chemical profiling using GCMS-Q-TOF, both done for first time for this weed, to assess the probable compounds present that could be linked to antidiabetic activity. Total phenolic and flavonoid contents along with DPPH radical scavenging assays were also done on five different extracts and fractions of M. pudica. Chemical class identification followed by derivetisation of the samples to analyse through GCMS was also done. Results showed good inhibitory activity against both the enzymes as compared to standard i.e. acarbose. At 1mg/mL, the MeOHi and EtOAc extracts showed two and three fold higher activity then the standard, respectively. Chemical profiling of all the extracts through GCMS- Q-TOF analysis identified organic acids, quinolone, quinone, phenolic compounds and dodecaborane as major constituents. Presence of highly radical scavenging dodecaborane is being reported for the 1st time in M. pudica. This study revealed that extracts of M. pudica is a rich source of phenolic compounds, dodecaborane, and organic acids and showed considerable high enzyme inhibitory activity. Extracts of M. pudica could be further subjected to isolation to identify the active principles responsible for its antidiabetic activity.
format	Conference or Workshop Item
author	Tunna, Tasnuva Sarwar Sarker, Md. Zaidul Islam Ahmed, Qamar Uddin Md. Jaffri, Juliana
author_facet	Tunna, Tasnuva Sarwar Sarker, Md. Zaidul Islam Ahmed, Qamar Uddin Md. Jaffri, Juliana
author_sort	Tunna, Tasnuva Sarwar
title	Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
title_short	Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
title_full	Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
title_fullStr	Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
title_full_unstemmed	Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro
title_sort	turning weeds into drugs: the prospect of mimosa pudica for diabetes mellitus in-vitro
publishDate	2014
url	http://irep.iium.edu.my/40672/ http://irep.iium.edu.my/40672/1/turning_weeds.pdf
first_indexed	2023-09-18T20:58:21Z
last_indexed	2023-09-18T20:58:21Z
_version_	1777410455560519680

Turning weeds into drugs: The prospect of Mimosa pudica for Diabetes mellitus in-vitro

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