Beyond anticoagulant: heparin as a potential anti-cancer agent

Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest...

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Main Authors:	Lokwani, Ravi, Azmi, Nina Suhaity, Mohd Yusoff, Mashitah, Arief Ichwan, Solachuddin Jauhari
Format:	Article
Language:	English
Published:	Hibiscus Publisher 2014
Subjects:	RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf

id	iium-40862
recordtype	eprints
spelling	iium-408622015-05-13T09:18:18Z http://irep.iium.edu.my/40862/ Beyond anticoagulant: heparin as a potential anti-cancer agent Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari RM300 Drugs and their action Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest the progression of tumors specially some solid forms of tumors such as small cell lung carcinoma and pancreatic tumors. The chemically modified and light molecular weight fractions of heparin have been found to be more active in countering tumor progression. In this review we discuss a brief history of this versatile biomolecule with its clinical data and postulated mechanism of action as per recent studies. This review also highlighted the approach of heparin-conjugated nanoparticles to achieve targeted drug delivery with synergistic response in tumor cells. Hibiscus Publisher 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf Lokwani, Ravi and Azmi, Nina Suhaity and Mohd Yusoff, Mashitah and Arief Ichwan, Solachuddin Jauhari (2014) Beyond anticoagulant: heparin as a potential anti-cancer agent. Journal of Biochemistry, Microbiology and Biotechnology, 2 (2). pp. 37-43. ISSN 2289-5779 http://journal.hibiscuspublisher.com/index.php/JOBIMB/article/view/160
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action
spellingShingle	RM300 Drugs and their action Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari Beyond anticoagulant: heparin as a potential anti-cancer agent
description	Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest the progression of tumors specially some solid forms of tumors such as small cell lung carcinoma and pancreatic tumors. The chemically modified and light molecular weight fractions of heparin have been found to be more active in countering tumor progression. In this review we discuss a brief history of this versatile biomolecule with its clinical data and postulated mechanism of action as per recent studies. This review also highlighted the approach of heparin-conjugated nanoparticles to achieve targeted drug delivery with synergistic response in tumor cells.
format	Article
author	Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari
author_facet	Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari
author_sort	Lokwani, Ravi
title	Beyond anticoagulant: heparin as a potential anti-cancer agent
title_short	Beyond anticoagulant: heparin as a potential anti-cancer agent
title_full	Beyond anticoagulant: heparin as a potential anti-cancer agent
title_fullStr	Beyond anticoagulant: heparin as a potential anti-cancer agent
title_full_unstemmed	Beyond anticoagulant: heparin as a potential anti-cancer agent
title_sort	beyond anticoagulant: heparin as a potential anti-cancer agent
publisher	Hibiscus Publisher
publishDate	2014
url	http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf
first_indexed	2023-09-18T20:58:33Z
last_indexed	2023-09-18T20:58:33Z
_version_	1777410468439130112

Beyond anticoagulant: heparin as a potential anti-cancer agent

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