Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats
Introduction: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ) -induced diabetes mellitus in rats. Methods: The effects of an aqueous extract of A. squamosa leaves on blood glucose, i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Singapore Medical Association
2008
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/40987/ http://irep.iium.edu.my/40987/ http://irep.iium.edu.my/40987/1/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf |
| Summary: | Introduction: The present study investigated the
possible therapeutic effects of Annona squamosa
(A. squamosa) extract on certain biochemical
markers in streptozotocin (STZ) -induced
diabetes mellitus in rats.
Methods: The effects of an aqueous extract of
A. squamosa leaves on blood glucose, insulin,
C-peptide, albumin, albumin/globulin ratio,
urea, uric acid and creatinine and the activities
of diagnostic marker enzymes aspartate
aminotransferase, alanine aminotransferase,
alkaline phosphatase and gamma-glutamyl
transpeptidase were examined in the plasma, liver
and kidney tissues of control and experimental
groups.
Results: Oral administration of A. squamosa (300
mg/kg) aqueous extract to diabetic rats for 30 days
significantly reduced blood glucose, urea, uric
acid and creatinine, but increased the activities
of insulin, C-peptide, albumin, albumin/globulin
ratio and restored all marker enzymes to near
control levels.
Conclusion: The present results shown that A.
squamosa extract has an antihyperglycaemic
effect and consequently may alleviate liver and
renal damage associated with STZ-induced
diabetes mellitus in rats.
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