Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi

Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibit...

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Main Authors: Ahmed, Qamar Uddin, N, Parveen, Khan, Nizam U, SM Kashif, R Zaidi, Singal, KC
Format: Article
Language:English
Published: Springer, Springer Korea Limited, Seoul, Korea (Rep.). 2003
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Online Access:http://irep.iium.edu.my/40989/
http://irep.iium.edu.my/40989/
http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf
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spelling iium-409892015-03-10T00:55:38Z http://irep.iium.edu.my/40989/ Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi Ahmed, Qamar Uddin N, Parveen Khan, Nizam U SM Kashif, R Zaidi Singal, KC Q Science (General) Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibition of spontaneous movements of the whole worm and the n.m. preparation of S. cervi,whereas aqueous extract caused inhibition of spontaneous movements of the n.m. preparation.The initial stimulatory effect was not observed by aqueous and alcoholic extracts on n.m.preparation while effect of alcoholic extract on the whole worm was characterized by an increasein the amplitude of contractions followed by reversible paralysis. The concentrations required toinhibit the movements of the whole worm and n.m. preparation for alcoholic extract of root were270mg/mL and 40 mg/mL, respectively whereas an aqueous extract caused inhibition of n.m.preparation at 30 mg/mL suggesting a cuticular permeability barrier. Alcoholic extract of the rootsof M. jalapa caused concentration related effect on the survival of microfilariae of S. cervi. The LC50and LC90 for alcoholic extract as observed after 6 hrs. were found to be 10 ng/mL and 18 ng/mL.,respectively. Springer, Springer Korea Limited, Seoul, Korea (Rep.). 2003 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf Ahmed, Qamar Uddin and N, Parveen and Khan, Nizam U and SM Kashif, R Zaidi and Singal, KC (2003) Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi. Oriental Pharmacy and Experimental Medicine, 3 (4). pp. 180-186. ISSN 1598-2386 http://opem.or.kr/bbs/board.php?bo_table=m02_12&wr_id=6
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic Q Science (General)
spellingShingle Q Science (General)
Ahmed, Qamar Uddin
N, Parveen
Khan, Nizam U
SM Kashif, R Zaidi
Singal, KC
Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
description Effect of aqueous and alcoholic extracts of the roots of Mirabilis jalapa Linn. Four Oclock plant, onthe spontaneous movements of both the whole worm and the nerve-muscle (n.m.) preparation ofSetaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract caused theinhibition of spontaneous movements of the whole worm and the n.m. preparation of S. cervi,whereas aqueous extract caused inhibition of spontaneous movements of the n.m. preparation.The initial stimulatory effect was not observed by aqueous and alcoholic extracts on n.m.preparation while effect of alcoholic extract on the whole worm was characterized by an increasein the amplitude of contractions followed by reversible paralysis. The concentrations required toinhibit the movements of the whole worm and n.m. preparation for alcoholic extract of root were270mg/mL and 40 mg/mL, respectively whereas an aqueous extract caused inhibition of n.m.preparation at 30 mg/mL suggesting a cuticular permeability barrier. Alcoholic extract of the rootsof M. jalapa caused concentration related effect on the survival of microfilariae of S. cervi. The LC50and LC90 for alcoholic extract as observed after 6 hrs. were found to be 10 ng/mL and 18 ng/mL.,respectively.
format Article
author Ahmed, Qamar Uddin
N, Parveen
Khan, Nizam U
SM Kashif, R Zaidi
Singal, KC
author_facet Ahmed, Qamar Uddin
N, Parveen
Khan, Nizam U
SM Kashif, R Zaidi
Singal, KC
author_sort Ahmed, Qamar Uddin
title Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_short Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_full Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_fullStr Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_full_unstemmed Antifilarial potential of the root extract of the Mirabilis jalapa Linn. (Nyctaginaceae) on cattle filarial parasite Setaria cervi
title_sort antifilarial potential of the root extract of the mirabilis jalapa linn. (nyctaginaceae) on cattle filarial parasite setaria cervi
publisher Springer, Springer Korea Limited, Seoul, Korea (Rep.).
publishDate 2003
url http://irep.iium.edu.my/40989/
http://irep.iium.edu.my/40989/
http://irep.iium.edu.my/40989/1/Antifilarial_potential_of_the_root_extract_of_the_Mirabilis_jalapa_Linn._%28Nyctaginaceae%29_on_cattle_filarial_parasite_Setaria_cervi.pdf
first_indexed 2023-09-18T20:58:43Z
last_indexed 2023-09-18T20:58:43Z
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