Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi

The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds ca...

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Main Authors:	Ahmed, Qamar Uddin, Parveen, Nazneen, Khan, N. U., Singhal, K. C.
Format:	Article
Language:	English
Published:	Elsevier Ireland Ltd 2002
Subjects:	QL Zoology
Online Access:	http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf

id	iium-41004
recordtype	eprints
spelling	iium-410042015-03-11T01:41:44Z http://irep.iium.edu.my/41004/ Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi Ahmed, Qamar Uddin Parveen, Nazneen Khan, N. U. Singhal, K. C. QL Zoology The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds caused the inhibition of spontaneous movements of the whole worm and the nerve muscle preparation of S. cervi , characterised by initial, short lasting small increase in tone of contractions followed by paralysis. The initial stimulatory effect was not observed by alcohol extract of leaves on nerve muscle preparation. The concentrations required to inhibit the movements of whole worm and nerve muscle preparations for alcohol extracts of leaves and seeds were 160, 30, and 150, 20 mg/ml, respectively suggesting a cuticular permeability barrier. Alcohol extracts of both leaves and seeds caused death of microfilariae in vitro, LC50 and LC90 being 15 and 25 ng/ml for alcohol extract of leaves and 12 and 18 ng/ml for alcohol extract of seeds,respectively. Elsevier Ireland Ltd 2002-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf Ahmed, Qamar Uddin and Parveen, Nazneen and Khan, N. U. and Singhal, K. C. (2002) Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi. Journal of Ethnopharmacology, 82 (1). pp. 23-28. ISSN 0378-8741 http://www.sciencedirect.com/science/article/pii/S0378874102001411 10.1016/S0378-8741(02)00141-1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QL Zoology
spellingShingle	QL Zoology Ahmed, Qamar Uddin Parveen, Nazneen Khan, N. U. Singhal, K. C. Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
description	The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia , on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcohol extracts of both leaves and seeds caused the inhibition of spontaneous movements of the whole worm and the nerve muscle preparation of S. cervi , characterised by initial, short lasting small increase in tone of contractions followed by paralysis. The initial stimulatory effect was not observed by alcohol extract of leaves on nerve muscle preparation. The concentrations required to inhibit the movements of whole worm and nerve muscle preparations for alcohol extracts of leaves and seeds were 160, 30, and 150, 20 mg/ml, respectively suggesting a cuticular permeability barrier. Alcohol extracts of both leaves and seeds caused death of microfilariae in vitro, LC50 and LC90 being 15 and 25 ng/ml for alcohol extract of leaves and 12 and 18 ng/ml for alcohol extract of seeds,respectively.
format	Article
author	Ahmed, Qamar Uddin Parveen, Nazneen Khan, N. U. Singhal, K. C.
author_facet	Ahmed, Qamar Uddin Parveen, Nazneen Khan, N. U. Singhal, K. C.
author_sort	Ahmed, Qamar Uddin
title	Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_short	Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_full	Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_fullStr	Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_full_unstemmed	Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi
title_sort	potential antifilarial activity of the leaves and seeds extracts of psoralea corylifolia on cattle filarial parasite setaria cervi
publisher	Elsevier Ireland Ltd
publishDate	2002
url	http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/ http://irep.iium.edu.my/41004/1/Potential_anti%EF%AC%81larial_activity_of_the_leaves_and_seeds_extracts_of_Psoralea_corylifolia.pdf
first_indexed	2023-09-18T20:58:44Z
last_indexed	2023-09-18T20:58:44Z
_version_	1777410480156966912

Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi

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