Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells
To investigate whether dysregulation of p53 phosphorylation confers tumor resistance to p53, we analysed the effects of wild-type p53 on oral squamous cell carcinoma(SCC) cell lines carrying various mutations of p53. Introduction of exogenous p53 neither induced apoptosis nor suppressed colony form...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature
2006
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/4137/ http://irep.iium.edu.my/4137/ http://irep.iium.edu.my/4137/ http://irep.iium.edu.my/4137/1/1209158a.pdf |