In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line

In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line

Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate. Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of ex...

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Main Authors: Ibrahim, Wisam Nabeel, Abdull Rasad, Mohammad Syaiful Baharii, Abdul Wahab, Ridhwan, Hashim, Ridzwan
Format: Conference or Workshop Item
Language:English
English
Published: 2014
Subjects:
QP Physiology
Online Access:http://irep.iium.edu.my/41532/
http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf
http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf
id iium-41532
recordtype eprints
spelling iium-415322018-05-05T17:40:26Z http://irep.iium.edu.my/41532/ In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line Ibrahim, Wisam Nabeel Abdull Rasad, Mohammad Syaiful Baharii Abdul Wahab, Ridhwan Hashim, Ridzwan QP Physiology Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate. Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of extra cellular matrix components and their role in tumor invasion and metastasis has been proven through many studies in many types of cancers. Many MMPs including all collagenases contain AP-1 DNA binding sites in their gene promoters, and they are transcriptionally regulated via this site. CTCF & Yb-1 transcription factors are among the many proteins which can bind specifically to AP-1 site of MMPs promoter gene. This study aimed to detect the interaction between CTCF or YB-1 transcription factors with the AP-1 site of MMP-13 gene promoter. This approach was performed to discover a probable therapeutic pathway through the effect of this protein – DNA interaction on the expression of MMP-13 which is a key factor in the process of malignant melanoma skin cancer invasion 2014-12 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf application/pdf en http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf Ibrahim, Wisam Nabeel and Abdull Rasad, Mohammad Syaiful Baharii and Abdul Wahab, Ridhwan and Hashim, Ridzwan (2014) In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line. In: International Health Conference IIUM 2014, 3rd-4th December 2014, Kuantan, Pahang. (Unpublished)
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic QP Physiology
spellingShingle QP Physiology
Ibrahim, Wisam Nabeel
Abdull Rasad, Mohammad Syaiful Baharii
Abdul Wahab, Ridhwan
Hashim, Ridzwan
In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
description Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate. Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of extra cellular matrix components and their role in tumor invasion and metastasis has been proven through many studies in many types of cancers. Many MMPs including all collagenases contain AP-1 DNA binding sites in their gene promoters, and they are transcriptionally regulated via this site. CTCF & Yb-1 transcription factors are among the many proteins which can bind specifically to AP-1 site of MMPs promoter gene. This study aimed to detect the interaction between CTCF or YB-1 transcription factors with the AP-1 site of MMP-13 gene promoter. This approach was performed to discover a probable therapeutic pathway through the effect of this protein – DNA interaction on the expression of MMP-13 which is a key factor in the process of malignant melanoma skin cancer invasion
format Conference or Workshop Item
author Ibrahim, Wisam Nabeel
Abdull Rasad, Mohammad Syaiful Baharii
Abdul Wahab, Ridhwan
Hashim, Ridzwan
author_facet Ibrahim, Wisam Nabeel
Abdull Rasad, Mohammad Syaiful Baharii
Abdul Wahab, Ridhwan
Hashim, Ridzwan
author_sort Ibrahim, Wisam Nabeel
title In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
title_short In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
title_full In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
title_fullStr In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
title_full_unstemmed In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
title_sort in vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
publishDate 2014
url http://irep.iium.edu.my/41532/
http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf
http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf
first_indexed 2023-09-18T20:59:28Z
last_indexed 2023-09-18T20:59:28Z
_version_ 1777410525948280832

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