Development and characterization of topical caffeine sunscreen formulation

Caffeine prominent property as a natural sunscreen has received recent interests in researches on topical formulations incorporating this organic compound. The main objective of this paper is to evaluate caffeine behaviours in a broad-spectrum sprayable sunscreen preparation. Two types of sunscreen...

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Main Authors:	Ab. Hadi, Hazrina, Rosli, Nur Amirah, Hamid, Zulfiki, Awadh, Ammar Ihsan Jawad
Format:	Article
Language:	English
Published:	Malaysian Pharmaceutical Society 2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/41643/ http://irep.iium.edu.my/41643/ http://irep.iium.edu.my/41643/1/41643.pdf

id	iium-41643
recordtype	eprints
spelling	iium-416432018-06-25T00:11:02Z http://irep.iium.edu.my/41643/ Development and characterization of topical caffeine sunscreen formulation Ab. Hadi, Hazrina Rosli, Nur Amirah Hamid, Zulfiki Awadh, Ammar Ihsan Jawad RS Pharmacy and materia medica Caffeine prominent property as a natural sunscreen has received recent interests in researches on topical formulations incorporating this organic compound. The main objective of this paper is to evaluate caffeine behaviours in a broad-spectrum sprayable sunscreen preparation. Two types of sunscreen formulations were developed with and without presence of 2% caffeine. Parameters that may influence the formulation stability were assessed. This includes organoleptic tests (appearance, colour, thickness, feel), physical tests (rheology and centrifugal phase separation) and chemical test (pH measure). Findings in both formulations were similar for organoleptic test parameters. Immediately after preparation, both formulations appeared as whitish fluid with low viscosity of almost watery-like. Upon spraying a small amount on hand, the texture is found to be smooth and easily spreadable on skin. The conditions remain stable and findings were similar even after 7 days storage at room temperature. The pH values were all measured alkaline approximately at room temperature. The addition of 10% of sodium hydroxide into the formulation majorly contributed to the measured alkalinity. Thus, caffeine did not significantly change the pH of the formulation. Both formulations produced almost the same results whereby they behave like non-viscous Newtonian fluids. Our findings also indicate no phase separation of all triplicate samples with and without 2% caffeine. Through the comprehensive study done, it can be concluded that caffeine has the potential to be used in topical sunscreen formulations as caffeine helps in enhancing activities of UV filters without affecting formulation stability. Malaysian Pharmaceutical Society 2015-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/41643/1/41643.pdf Ab. Hadi, Hazrina and Rosli, Nur Amirah and Hamid, Zulfiki and Awadh, Ammar Ihsan Jawad (2015) Development and characterization of topical caffeine sunscreen formulation. Malaysian Journal of Pharmacy, 2 (1). p. 162. ISSN 1675-3666 http://www.mps.org.my/index.cfm?&menuid=146
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ab. Hadi, Hazrina Rosli, Nur Amirah Hamid, Zulfiki Awadh, Ammar Ihsan Jawad Development and characterization of topical caffeine sunscreen formulation
description	Caffeine prominent property as a natural sunscreen has received recent interests in researches on topical formulations incorporating this organic compound. The main objective of this paper is to evaluate caffeine behaviours in a broad-spectrum sprayable sunscreen preparation. Two types of sunscreen formulations were developed with and without presence of 2% caffeine. Parameters that may influence the formulation stability were assessed. This includes organoleptic tests (appearance, colour, thickness, feel), physical tests (rheology and centrifugal phase separation) and chemical test (pH measure). Findings in both formulations were similar for organoleptic test parameters. Immediately after preparation, both formulations appeared as whitish fluid with low viscosity of almost watery-like. Upon spraying a small amount on hand, the texture is found to be smooth and easily spreadable on skin. The conditions remain stable and findings were similar even after 7 days storage at room temperature. The pH values were all measured alkaline approximately at room temperature. The addition of 10% of sodium hydroxide into the formulation majorly contributed to the measured alkalinity. Thus, caffeine did not significantly change the pH of the formulation. Both formulations produced almost the same results whereby they behave like non-viscous Newtonian fluids. Our findings also indicate no phase separation of all triplicate samples with and without 2% caffeine. Through the comprehensive study done, it can be concluded that caffeine has the potential to be used in topical sunscreen formulations as caffeine helps in enhancing activities of UV filters without affecting formulation stability.
format	Article
author	Ab. Hadi, Hazrina Rosli, Nur Amirah Hamid, Zulfiki Awadh, Ammar Ihsan Jawad
author_facet	Ab. Hadi, Hazrina Rosli, Nur Amirah Hamid, Zulfiki Awadh, Ammar Ihsan Jawad
author_sort	Ab. Hadi, Hazrina
title	Development and characterization of topical caffeine sunscreen formulation
title_short	Development and characterization of topical caffeine sunscreen formulation
title_full	Development and characterization of topical caffeine sunscreen formulation
title_fullStr	Development and characterization of topical caffeine sunscreen formulation
title_full_unstemmed	Development and characterization of topical caffeine sunscreen formulation
title_sort	development and characterization of topical caffeine sunscreen formulation
publisher	Malaysian Pharmaceutical Society
publishDate	2015
url	http://irep.iium.edu.my/41643/ http://irep.iium.edu.my/41643/ http://irep.iium.edu.my/41643/1/41643.pdf
first_indexed	2023-09-18T20:59:34Z
last_indexed	2023-09-18T20:59:34Z
_version_	1777410532527046656

Development and characterization of topical caffeine sunscreen formulation

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