Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
Sea cucumbers are marine invertebrates of the phylum of Echinodermata that have been used in Asian traditional medicine since ancient times. This study was conducted to investigate the antioxidant and cytotoxic properties of aqueous and organic extracts from two sea cucumber species, Holothuria ed...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Akadémiai Kiadó
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/1/2013-Acta_Biologica_Hungarica_.pdf |
| Summary: | Sea cucumbers are marine invertebrates of the phylum of Echinodermata that have been used in Asian
traditional medicine since ancient times. This study was conducted to investigate the antioxidant and cytotoxic
properties of aqueous and organic extracts from two sea cucumber species, Holothuria edulis Lesson
(Holothuriidae) and Stichopus horrens Selenka (Stichopodidae). Antioxidant activities of the extracts were
used to demonstrate the cytotoxic effects of the extracts against two human cancer cell lines, non-small cell
lung cancer cells (A549) and esophageal cancer cells (TE1). The results showed that both aqueous and
organic extracts of H. edulis were able to scavenge DPPH radical (IC50 at 2.04 mg/ml and 8.73 mg/ml,
respectively). Aqueous and organic extracts of S. horrens
oxidation by linoleate free radical. On the other hand, the organic extract of S. horrens exhibited the highest
cytotoxic effects against A549 and TE1 cancer cells giving IC50 at 15.5 and 4.0 μg/ml, respectively. In
conclusion, the present study revealed that H. edulis and S. horrens contain promising levels of antioxidant |
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