Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies

The prevalence of diabetes mellitus among Malaysians adults more than 30 years of age has escalated by more than two fold over a 20-year period. Diabetes mellitus is a chronic disorder together with other metabolic abnormalities, usually developed due to insulin resistance or deficiency as well as i...

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Main Authors:	Arfin, Mehnaz, Ahmed, Qamar Uddin, Mat So'ad, Siti Zaiton, Wan Sulaiman, Wan Azizi, Bakhtiar, M. Taher, Saxena, Anil Kumar
Format:	Conference or Workshop Item
Language:	English English
Published:	2014
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/41905/ http://irep.iium.edu.my/41905/ http://irep.iium.edu.my/41905/1/IRIIE_2014_Poster_ID_Sister_Mehnaz_Dr._Qamar_Uddin_Ahmed_Isolation_of_a_promising_anti-diabetic_agent_from_the_leaves_of_Malaysian_herb_%E2%80%9CTetracera_indica%E2%80%9D_and_toxicological_studies.pdf http://irep.iium.edu.my/41905/4/qamar_uddin.pdf

id	iium-41905
recordtype	eprints
spelling	iium-419052018-06-18T13:17:22Z http://irep.iium.edu.my/41905/ Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies Arfin, Mehnaz Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Wan Sulaiman, Wan Azizi Bakhtiar, M. Taher Saxena, Anil Kumar R Medicine (General) The prevalence of diabetes mellitus among Malaysians adults more than 30 years of age has escalated by more than two fold over a 20-year period. Diabetes mellitus is a chronic disorder together with other metabolic abnormalities, usually developed due to insulin resistance or deficiency as well as increased hepatic glucose output. On the other hand, many plants have been used for the treatment of diabetes mellitus in modern system of medicine and in other ancient systems of the world. As a result, plants are now-a-days regarded as promising and significantly attractive natural sources to enrich the current therapy options against diabetes. However, so far, not many active agents have been successfully isolated and extensively studied. Hence, in the current research, we are prompted to evaluate the antidiabetic potential of a flavonoid (5,7-dihydroxy-8-methoxyflavone) isolated from the leaves of Tetracera indica Merr., a Malaysian medicinal plant which is traditionally used to treat diabetes in Malaysia. The study was carried out using Sprague-Dawley rats (diabetic as well as normal) to evaluate antidiabetic potential of 5,7-dihydroxy-8-methoxyflavone at at 5 mg/kg b.w. and 25 mg/kg b.w. It exhibited significant anti-hyperglycemic activity in alloxan induced diabetic rats, however in normal rats, no hypoglycemic activity was observed, when compared with +ve and –ve controlled groups. The antidiabetic activity was found to be comparable with glibenclamide (GLBC), a known oral hypoglycemic agent (50 mg/kg b.w.). The LD50 of 5,7-dihydroxy-8-methoxyflavone extracts was found to be more than 500 mg/kg b.w. and no lethal toxicity was observed within this range. Three weeks later the In-vivo study, histopathology of kidney and pancreas from alloxan-induced rats demonstrated the clinical manifestation of diabetic affected kidney and pancreas. It is concluded that the isolated flavonoid (5,7-dihydroxy-8-methoxyflavone) from the leaves of T. indica is a promising antidiabetic agent and could prove useful in the management of diabetes. 2014-06-11 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/41905/1/IRIIE_2014_Poster_ID_Sister_Mehnaz_Dr._Qamar_Uddin_Ahmed_Isolation_of_a_promising_anti-diabetic_agent_from_the_leaves_of_Malaysian_herb_%E2%80%9CTetracera_indica%E2%80%9D_and_toxicological_studies.pdf application/pdf en http://irep.iium.edu.my/41905/4/qamar_uddin.pdf Arfin, Mehnaz and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Wan Sulaiman, Wan Azizi and Bakhtiar, M. Taher and Saxena, Anil Kumar (2014) Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Cultural Activity Center (CAC), Internatioanal Islamic University Malaysia. http://www.iium.edu.my/irie/14/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Arfin, Mehnaz Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Wan Sulaiman, Wan Azizi Bakhtiar, M. Taher Saxena, Anil Kumar Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
description	The prevalence of diabetes mellitus among Malaysians adults more than 30 years of age has escalated by more than two fold over a 20-year period. Diabetes mellitus is a chronic disorder together with other metabolic abnormalities, usually developed due to insulin resistance or deficiency as well as increased hepatic glucose output. On the other hand, many plants have been used for the treatment of diabetes mellitus in modern system of medicine and in other ancient systems of the world. As a result, plants are now-a-days regarded as promising and significantly attractive natural sources to enrich the current therapy options against diabetes. However, so far, not many active agents have been successfully isolated and extensively studied. Hence, in the current research, we are prompted to evaluate the antidiabetic potential of a flavonoid (5,7-dihydroxy-8-methoxyflavone) isolated from the leaves of Tetracera indica Merr., a Malaysian medicinal plant which is traditionally used to treat diabetes in Malaysia. The study was carried out using Sprague-Dawley rats (diabetic as well as normal) to evaluate antidiabetic potential of 5,7-dihydroxy-8-methoxyflavone at at 5 mg/kg b.w. and 25 mg/kg b.w. It exhibited significant anti-hyperglycemic activity in alloxan induced diabetic rats, however in normal rats, no hypoglycemic activity was observed, when compared with +ve and –ve controlled groups. The antidiabetic activity was found to be comparable with glibenclamide (GLBC), a known oral hypoglycemic agent (50 mg/kg b.w.). The LD50 of 5,7-dihydroxy-8-methoxyflavone extracts was found to be more than 500 mg/kg b.w. and no lethal toxicity was observed within this range. Three weeks later the In-vivo study, histopathology of kidney and pancreas from alloxan-induced rats demonstrated the clinical manifestation of diabetic affected kidney and pancreas. It is concluded that the isolated flavonoid (5,7-dihydroxy-8-methoxyflavone) from the leaves of T. indica is a promising antidiabetic agent and could prove useful in the management of diabetes.
format	Conference or Workshop Item
author	Arfin, Mehnaz Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Wan Sulaiman, Wan Azizi Bakhtiar, M. Taher Saxena, Anil Kumar
author_facet	Arfin, Mehnaz Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Wan Sulaiman, Wan Azizi Bakhtiar, M. Taher Saxena, Anil Kumar
author_sort	Arfin, Mehnaz
title	Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
title_short	Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
title_full	Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
title_fullStr	Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
title_full_unstemmed	Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies
title_sort	isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of malaysian herb “tetracera indica” and its in vivo toxicological studies
publishDate	2014
url	http://irep.iium.edu.my/41905/ http://irep.iium.edu.my/41905/ http://irep.iium.edu.my/41905/1/IRIIE_2014_Poster_ID_Sister_Mehnaz_Dr._Qamar_Uddin_Ahmed_Isolation_of_a_promising_anti-diabetic_agent_from_the_leaves_of_Malaysian_herb_%E2%80%9CTetracera_indica%E2%80%9D_and_toxicological_studies.pdf http://irep.iium.edu.my/41905/4/qamar_uddin.pdf
first_indexed	2023-09-18T20:59:52Z
last_indexed	2023-09-18T20:59:52Z
_version_	1777410551412948992

Isolation of a promising anti-diabetic agent (5,7-dihydroxy-8-methoxyflavone) from the leaves of Malaysian herb “Tetracera indica” and its in vivo toxicological studies

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