Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion

Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 t...

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Main Authors:	John, Akbar, Khan Chowdhury, Ahmed Jalal, Yunus, Kamaruzzaman, Kasim, Zaleha
Format:	Article
Language:	English
Published:	Asian Network for Scientific Information 2010
Subjects:	QL Zoology
Online Access:	http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/1/1930-1936.pdf

id	iium-4215
recordtype	eprints
spelling	iium-42152017-12-07T04:55:08Z http://irep.iium.edu.my/4215/ Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion John, Akbar Khan Chowdhury, Ahmed Jalal Yunus, Kamaruzzaman Kasim, Zaleha QL Zoology Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 times more sensitive than the United States Pharmacopeial (USP) rabbit pyrogen test method. It should be noted that major differences among the LAL preparations lie in the area of sensitivity. Differences, up to 100-fold, exist in the sensitivity of the various LAL preparations to the same endotoxin. It is also considerate that the Information on the molecular level interaction between horseshoe crab blood and endotoxin would provide detailed information about the clotting process. Based on the above perspective review of literature was established to elucidate the compounds involved in the clot formation in horseshoe crab blood while encountering with bacterial endotoxin. Since LAL preparation is important for its application in clinical, pharmaceutical, public health and environmental areas, this paper will also discuss some molecular level details in Lysated Amebocyte interaction in clot formation Asian Network for Scientific Information 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/4215/1/1930-1936.pdf John, Akbar and Khan Chowdhury, Ahmed Jalal and Yunus, Kamaruzzaman and Kasim, Zaleha (2010) Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion. Journal of Applied Sciences, 10 (17). pp. 1930-1936. ISSN 1812-5662 (O), 1812-5654 (P) http://scialert.net/abstract/?doi=jas.2010.1930.1936 10.3923/jas.2010.1930.1936
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QL Zoology
spellingShingle	QL Zoology John, Akbar Khan Chowdhury, Ahmed Jalal Yunus, Kamaruzzaman Kasim, Zaleha Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
description	Endotoxins from gram-negative microorganisms initiates clot formation in blood when it is accidentally encountered by horseshoe crab. This property was extensively studied by various researchers as a result Limulus Amebocyte Lysate (LAL) test was established. The LAL tests in general were 3 to 300 times more sensitive than the United States Pharmacopeial (USP) rabbit pyrogen test method. It should be noted that major differences among the LAL preparations lie in the area of sensitivity. Differences, up to 100-fold, exist in the sensitivity of the various LAL preparations to the same endotoxin. It is also considerate that the Information on the molecular level interaction between horseshoe crab blood and endotoxin would provide detailed information about the clotting process. Based on the above perspective review of literature was established to elucidate the compounds involved in the clot formation in horseshoe crab blood while encountering with bacterial endotoxin. Since LAL preparation is important for its application in clinical, pharmaceutical, public health and environmental areas, this paper will also discuss some molecular level details in Lysated Amebocyte interaction in clot formation
format	Article
author	John, Akbar Khan Chowdhury, Ahmed Jalal Yunus, Kamaruzzaman Kasim, Zaleha
author_facet	John, Akbar Khan Chowdhury, Ahmed Jalal Yunus, Kamaruzzaman Kasim, Zaleha
author_sort	John, Akbar
title	Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_short	Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_full	Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_fullStr	Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_full_unstemmed	Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
title_sort	mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion
publisher	Asian Network for Scientific Information
publishDate	2010
url	http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/ http://irep.iium.edu.my/4215/1/1930-1936.pdf
first_indexed	2023-09-18T20:12:21Z
last_indexed	2023-09-18T20:12:21Z
_version_	1777407561579888640

Mechanism in the clot formation of horseshoe crab blood during bacterial endotoxin invasion

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