A study on the effects of different levels of data on the overall meta-analysis estimates

Meta-analysis that pools two levels of data, namely, aggregate data (AD) and individual patient data (IPD) is increasingly common. The implications of pooling these data on the overall meta-analysis estimates have not been fully explored. We examined some of the statistical properties of overall est...

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Main Authors:	Nik Idris, Nik Ruzni, Abdullah, Mimi Hafizah
Format:	Article
Language:	English
Published:	Pushpa Publishing House 2015
Subjects:	QA Mathematics
Online Access:	http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/1/06--73-86--PPH-1409008-MS_-_Final_version.pdf

id	iium-42216
recordtype	eprints
spelling	iium-422162015-07-31T07:50:41Z http://irep.iium.edu.my/42216/ A study on the effects of different levels of data on the overall meta-analysis estimates Nik Idris, Nik Ruzni Abdullah, Mimi Hafizah QA Mathematics Meta-analysis that pools two levels of data, namely, aggregate data (AD) and individual patient data (IPD) is increasingly common. The implications of pooling these data on the overall meta-analysis estimates have not been fully explored. We examined some of the statistical properties of overall estimate of the treatment effects from meta-analysis which combine the AD and IPD studies. We compared these estimates with those from the all-AD and all-IPD meta-analyses in terms of the bias, root-mean-square-error and coverage probability. We used simulated meta-analyses to evaluate the behaviour of these estimates. The results indicated superiority of estimates from IPD meta-analysis, compared to those from combined-level studies and AD studies, in terms of the accuracy and efficiency of the estimates. Additionally, for the same statistical properties examined, the estimates from combined-level studies displayed better results over those from all-AD meta-analysis. In the scenario involving different ratios of AD:IPD, we found that combined-level studies generated estimates with better statistical properties, irrelevant of the composition of the AD:IPD ratio. Therefore, whenever possible, we recommend the inclusion of available IPD studies when conducting traditional AD meta-analysis. Pushpa Publishing House 2015-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42216/1/06--73-86--PPH-1409008-MS_-_Final_version.pdf Nik Idris, Nik Ruzni and Abdullah, Mimi Hafizah (2015) A study on the effects of different levels of data on the overall meta-analysis estimates. Far East Journal of Mathematical Sciences (FJMS), 96 (1). pp. 73-86. ISSN 0972-0871 http://www.pphmj.com/journals/fjms.htm http://dx.doi.org/10.17654/FJMSJan2015_073_086
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QA Mathematics
spellingShingle	QA Mathematics Nik Idris, Nik Ruzni Abdullah, Mimi Hafizah A study on the effects of different levels of data on the overall meta-analysis estimates
description	Meta-analysis that pools two levels of data, namely, aggregate data (AD) and individual patient data (IPD) is increasingly common. The implications of pooling these data on the overall meta-analysis estimates have not been fully explored. We examined some of the statistical properties of overall estimate of the treatment effects from meta-analysis which combine the AD and IPD studies. We compared these estimates with those from the all-AD and all-IPD meta-analyses in terms of the bias, root-mean-square-error and coverage probability. We used simulated meta-analyses to evaluate the behaviour of these estimates. The results indicated superiority of estimates from IPD meta-analysis, compared to those from combined-level studies and AD studies, in terms of the accuracy and efficiency of the estimates. Additionally, for the same statistical properties examined, the estimates from combined-level studies displayed better results over those from all-AD meta-analysis. In the scenario involving different ratios of AD:IPD, we found that combined-level studies generated estimates with better statistical properties, irrelevant of the composition of the AD:IPD ratio. Therefore, whenever possible, we recommend the inclusion of available IPD studies when conducting traditional AD meta-analysis.
format	Article
author	Nik Idris, Nik Ruzni Abdullah, Mimi Hafizah
author_facet	Nik Idris, Nik Ruzni Abdullah, Mimi Hafizah
author_sort	Nik Idris, Nik Ruzni
title	A study on the effects of different levels of data on the overall meta-analysis estimates
title_short	A study on the effects of different levels of data on the overall meta-analysis estimates
title_full	A study on the effects of different levels of data on the overall meta-analysis estimates
title_fullStr	A study on the effects of different levels of data on the overall meta-analysis estimates
title_full_unstemmed	A study on the effects of different levels of data on the overall meta-analysis estimates
title_sort	study on the effects of different levels of data on the overall meta-analysis estimates
publisher	Pushpa Publishing House
publishDate	2015
url	http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/ http://irep.iium.edu.my/42216/1/06--73-86--PPH-1409008-MS_-_Final_version.pdf
first_indexed	2023-09-18T21:00:14Z
last_indexed	2023-09-18T21:00:14Z
_version_	1777410574030733312

A study on the effects of different levels of data on the overall meta-analysis estimates

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