Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells

Mesenchymal stem cells (MSCs) are considered a potential tool for cell based regenerative therapy due to their immunomodulatory property, differentiation potentials, trophic activity as well as large donor pool. Poor engraftment and short term survival of transplanted MSCs are recognized as major li...

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Main Authors:	Haque, Nazmul, Abu Kasim, Noor Hayaty, Rahman, Mohammad Tariqur
Format:	Article
Language:	English English
Published:	Ivyspring International Publisher. 2015
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/1/Int_J_Biol_Sci_2015_11_324-334_DoI_10_7150_ijbs_10567.pdf http://irep.iium.edu.my/42326/4/42326_Optimization%20of%20pre-transplantation%20conditions_SCOPUS.pdf

id	iium-42326
recordtype	eprints
spelling	iium-423262017-11-08T04:18:08Z http://irep.iium.edu.my/42326/ Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells Haque, Nazmul Abu Kasim, Noor Hayaty Rahman, Mohammad Tariqur RM Therapeutics. Pharmacology Mesenchymal stem cells (MSCs) are considered a potential tool for cell based regenerative therapy due to their immunomodulatory property, differentiation potentials, trophic activity as well as large donor pool. Poor engraftment and short term survival of transplanted MSCs are recognized as major limitations which were linked to early cellular ageing, loss of chemokine markers during ex vivo expansion, and hyper-immunogenicity to xeno-contaminated MSCs. These problems can be minimized by ex vivo expansion of MSCs in hypoxic culture condition using well defined or xeno-free media i.e., media supplemented with growth factors, human serum or platelet lysate. In addition to ex vivo expansion in hypoxic culture condition using well defined media, this review article describes the potentials of transient adaptation of expanded MSCs in autologous serum supplemented medium prior to transplantation for long term regenerative benefits. Such transient adaptation in autologous serum supplemented medium may help to increase chemokine receptor expression and tissue specific differentiation of ex vivo expanded MSCs, thus would provide long term regenerative benefits. Ivyspring International Publisher. 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42326/1/Int_J_Biol_Sci_2015_11_324-334_DoI_10_7150_ijbs_10567.pdf application/pdf en http://irep.iium.edu.my/42326/4/42326_Optimization%20of%20pre-transplantation%20conditions_SCOPUS.pdf Haque, Nazmul and Abu Kasim, Noor Hayaty and Rahman, Mohammad Tariqur (2015) Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells. International Journal of Biological Sciences, 11 (3). pp. 324-334. ISSN 1449-2288 http://www.ijbs.com/ 10.7150/ijbs.10567
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Haque, Nazmul Abu Kasim, Noor Hayaty Rahman, Mohammad Tariqur Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
description	Mesenchymal stem cells (MSCs) are considered a potential tool for cell based regenerative therapy due to their immunomodulatory property, differentiation potentials, trophic activity as well as large donor pool. Poor engraftment and short term survival of transplanted MSCs are recognized as major limitations which were linked to early cellular ageing, loss of chemokine markers during ex vivo expansion, and hyper-immunogenicity to xeno-contaminated MSCs. These problems can be minimized by ex vivo expansion of MSCs in hypoxic culture condition using well defined or xeno-free media i.e., media supplemented with growth factors, human serum or platelet lysate. In addition to ex vivo expansion in hypoxic culture condition using well defined media, this review article describes the potentials of transient adaptation of expanded MSCs in autologous serum supplemented medium prior to transplantation for long term regenerative benefits. Such transient adaptation in autologous serum supplemented medium may help to increase chemokine receptor expression and tissue specific differentiation of ex vivo expanded MSCs, thus would provide long term regenerative benefits.
format	Article
author	Haque, Nazmul Abu Kasim, Noor Hayaty Rahman, Mohammad Tariqur
author_facet	Haque, Nazmul Abu Kasim, Noor Hayaty Rahman, Mohammad Tariqur
author_sort	Haque, Nazmul
title	Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
title_short	Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
title_full	Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
title_fullStr	Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
title_full_unstemmed	Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
title_sort	optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells
publisher	Ivyspring International Publisher.
publishDate	2015
url	http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/ http://irep.iium.edu.my/42326/1/Int_J_Biol_Sci_2015_11_324-334_DoI_10_7150_ijbs_10567.pdf http://irep.iium.edu.my/42326/4/42326_Optimization%20of%20pre-transplantation%20conditions_SCOPUS.pdf
first_indexed	2023-09-18T21:00:21Z
last_indexed	2023-09-18T21:00:21Z
_version_	1777410581582577664

Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells

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