Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum

Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antiox...

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Main Authors:	Aminudin, Nurul Iman, Ahmad, Farediah, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf

id	iium-42497
recordtype	eprints
spelling	iium-424972015-05-07T06:55:14Z http://irep.iium.edu.my/42497/ Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher RS Pharmacy and materia medica Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antioxidant, cholinesterase and tyrosinase enzymatic inhibition activities of leaves and heartwood of Calophyllum symingtonianum, and the bark of Calophyllum depressinervosum were conducted. All extracts were tested for their total phenolic content and antioxidant activities by DPPH radical scavenging and β-carotene bleaching. Cholinesterase inhibition by Ellman’s method and tyrosinase inhibition using L-DOPA as a substrate were also tested. All methanol extracts were found to exhibit strong DPPH radical scavenging effects. The methanol extract of C. depressinervosum bark showed 95.08% inhibition of β-carotene bleaching and 78.46% inhibition against butyrylcholinesterase (BChE). All extracts showed moderate inhibition towards tyrosinase activity with an IC50 of more than 100 μg/mL. 2015-03 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf application/pdf en http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher (2015) Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum. In: International Conference on Natural Products 2015, 24-25 March 2015, Double Tree by Hilton, Johor Bahru. (Unpublished) http://science.utm.my/icnp2015/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
description	Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antioxidant, cholinesterase and tyrosinase enzymatic inhibition activities of leaves and heartwood of Calophyllum symingtonianum, and the bark of Calophyllum depressinervosum were conducted. All extracts were tested for their total phenolic content and antioxidant activities by DPPH radical scavenging and β-carotene bleaching. Cholinesterase inhibition by Ellman’s method and tyrosinase inhibition using L-DOPA as a substrate were also tested. All methanol extracts were found to exhibit strong DPPH radical scavenging effects. The methanol extract of C. depressinervosum bark showed 95.08% inhibition of β-carotene bleaching and 78.46% inhibition against butyrylcholinesterase (BChE). All extracts showed moderate inhibition towards tyrosinase activity with an IC50 of more than 100 μg/mL.
format	Conference or Workshop Item
author	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher
author_facet	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher
author_sort	Aminudin, Nurul Iman
title	Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
title_short	Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
title_full	Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
title_fullStr	Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
title_full_unstemmed	Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
title_sort	antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
publishDate	2015
url	http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf
first_indexed	2023-09-18T21:00:35Z
last_indexed	2023-09-18T21:00:35Z
_version_	1777410596857184256

Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum

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