MEMS biosensor for potential cancer cell detection

Typically, cancer diagnosis relies on morphological examination of surgically removed tissue samples. However, diagnosis based on morphological examination is difficult, not accurate and often requires large amounts of biological materials. Thus, additional more accurate markers are needed to fur...

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Main Authors:	Zakaria, Nor Hisyamuddin, Nordin, Anis Nurashikin, Mel, Maizirwan, Arifuzzaman, Sayeed M ., Voiculescu, Ioana
Format:	Conference or Workshop Item
Language:	English
Published:	2009
Subjects:	TK Electrical engineering. Electronics Nuclear engineering TK452 Electric apparatus and materials. Electric circuits. Electric networks TP250 Industrial electrochemistry
Online Access:	http://irep.iium.edu.my/4269/ http://irep.iium.edu.my/4269/ http://irep.iium.edu.my/4269/1/IMECE2009-10537-1.pdf

id	iium-4269
recordtype	eprints
spelling	iium-42692011-11-16T01:01:05Z http://irep.iium.edu.my/4269/ MEMS biosensor for potential cancer cell detection Zakaria, Nor Hisyamuddin Nordin, Anis Nurashikin Mel, Maizirwan Arifuzzaman, Sayeed M . Voiculescu, Ioana TK Electrical engineering. Electronics Nuclear engineering TK452 Electric apparatus and materials. Electric circuits. Electric networks TP250 Industrial electrochemistry Typically, cancer diagnosis relies on morphological examination of surgically removed tissue samples. However, diagnosis based on morphological examination is difficult, not accurate and often requires large amounts of biological materials. Thus, additional more accurate markers are needed to further increase the diagnostic accuracy of cancer cells. Despite having similar morphological features, the cancer and normal cell populations show significantly different mechanical properties. The mechanical properties of cancer cells that have been identified as important factors for the diagnosis of cancer are the cell stiffness or elasticity and cell adhesion. We present an acoustic resonant platform that is used in liquid environments and it is able to monitor the attachment of normal and cancer cell lines. The biosensor is based on a MEMS sheer horizontal surface acoustic wave (SH-SAW) piezoelectric resonator. We consider the SH-SAW piezoelectric resonator because it is better suited for liquid sensing applications due to the minimal damping of the acoustic wave. The miniature size of this biosensor allows us to perform single cell electrical measurements which will provide information on the progression of cell adhesion, cell growth and viscoelasticity changes of normal and cancer cells. A commercial quartz crystal microbalance (QCM) is initially used to study the cell attachment process and correlate the relationship between the electrical measurements and the mechanical properties of cells. The commercial QCM could be used as a functional biosensor utilizing living cells as biological signal transduction elements. 2009-11-13 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/4269/1/IMECE2009-10537-1.pdf Zakaria, Nor Hisyamuddin and Nordin, Anis Nurashikin and Mel, Maizirwan and Arifuzzaman, Sayeed M . and Voiculescu, Ioana (2009) MEMS biosensor for potential cancer cell detection. In: ASME International Mechanical Engineering Congress & Exposition (ASME 2009), 13-19 November, 2009, Lake Buena Vista, Florida, USA. http://www.link.aip.org/link/abstract/ASMECP/v2009/i43857/p799/s1
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TK Electrical engineering. Electronics Nuclear engineering TK452 Electric apparatus and materials. Electric circuits. Electric networks TP250 Industrial electrochemistry
spellingShingle	TK Electrical engineering. Electronics Nuclear engineering TK452 Electric apparatus and materials. Electric circuits. Electric networks TP250 Industrial electrochemistry Zakaria, Nor Hisyamuddin Nordin, Anis Nurashikin Mel, Maizirwan Arifuzzaman, Sayeed M . Voiculescu, Ioana MEMS biosensor for potential cancer cell detection
description	Typically, cancer diagnosis relies on morphological examination of surgically removed tissue samples. However, diagnosis based on morphological examination is difficult, not accurate and often requires large amounts of biological materials. Thus, additional more accurate markers are needed to further increase the diagnostic accuracy of cancer cells. Despite having similar morphological features, the cancer and normal cell populations show significantly different mechanical properties. The mechanical properties of cancer cells that have been identified as important factors for the diagnosis of cancer are the cell stiffness or elasticity and cell adhesion. We present an acoustic resonant platform that is used in liquid environments and it is able to monitor the attachment of normal and cancer cell lines. The biosensor is based on a MEMS sheer horizontal surface acoustic wave (SH-SAW) piezoelectric resonator. We consider the SH-SAW piezoelectric resonator because it is better suited for liquid sensing applications due to the minimal damping of the acoustic wave. The miniature size of this biosensor allows us to perform single cell electrical measurements which will provide information on the progression of cell adhesion, cell growth and viscoelasticity changes of normal and cancer cells. A commercial quartz crystal microbalance (QCM) is initially used to study the cell attachment process and correlate the relationship between the electrical measurements and the mechanical properties of cells. The commercial QCM could be used as a functional biosensor utilizing living cells as biological signal transduction elements.
format	Conference or Workshop Item
author	Zakaria, Nor Hisyamuddin Nordin, Anis Nurashikin Mel, Maizirwan Arifuzzaman, Sayeed M . Voiculescu, Ioana
author_facet	Zakaria, Nor Hisyamuddin Nordin, Anis Nurashikin Mel, Maizirwan Arifuzzaman, Sayeed M . Voiculescu, Ioana
author_sort	Zakaria, Nor Hisyamuddin
title	MEMS biosensor for potential cancer cell detection
title_short	MEMS biosensor for potential cancer cell detection
title_full	MEMS biosensor for potential cancer cell detection
title_fullStr	MEMS biosensor for potential cancer cell detection
title_full_unstemmed	MEMS biosensor for potential cancer cell detection
title_sort	mems biosensor for potential cancer cell detection
publishDate	2009
url	http://irep.iium.edu.my/4269/ http://irep.iium.edu.my/4269/ http://irep.iium.edu.my/4269/1/IMECE2009-10537-1.pdf
first_indexed	2023-09-18T20:12:26Z
last_indexed	2023-09-18T20:12:26Z
_version_	1777407567301967872

MEMS biosensor for potential cancer cell detection

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