Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subje...

Full description

Bibliographic Details
Main Authors:	Zakaria, Bannur, Mohd Zaki, Salleh, Hashim, Hazwanie, Tom, Hennessy, Md Nor, Azmi, MH, Zailani, Prabu, Ramasamy, ZA, Zakaria, Suneet, S, Ngow, Harris Abdullah, Henry, Guy M., Teh, Laykek
Format:	Article
Language:	English English
Published:	International Journal of Pharmacy and Pharmaceutical Sciences ( IJPPS) 2014
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/42698/ http://irep.iium.edu.my/42698/ http://irep.iium.edu.my/42698/1/metabolomics_and_pharmacogenetics_based_5-fluorouracil_monitoring_in_colorectal_cancer_patients.pdf http://irep.iium.edu.my/42698/4/42698_METABOLOMICS_scopus.pdf

id	iium-42698
recordtype	eprints
spelling	iium-426982017-09-21T05:12:38Z http://irep.iium.edu.my/42698/ Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients Zakaria, Bannur Mohd Zaki, Salleh Hashim, Hazwanie Tom, Hennessy Md Nor, Azmi MH, Zailani Prabu, Ramasamy ZA, Zakaria Suneet, S Ngow, Harris Abdullah Henry, Guy M. Teh, Laykek RC Internal medicine Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subjects were genotyped for UGT1A128, DPYD 1896 T>C and DPYD5. Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. The predictive PLSDA model revealed 100% accuracy of metabolites differentiating CRC patients and healthy volunteers. In addition, the metabolic profiles associated with different genotypes of DPYD and UGT1A1 explains the impact of genetic variation on differential drug responses. Conclusion: Pharmacogenetics and metabolomics profiles are potential platforms for more comprehensive monitoring of patient's disease progress and drug response. Further study is however needed to validate the use of biomarkers identified. Keywords: Metabolomics, Pharmacogenetics, Polymorphism, Colorectal cancer (CRC), 5-fluorouracil (5-FU) International Journal of Pharmacy and Pharmaceutical Sciences ( IJPPS) 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/42698/1/metabolomics_and_pharmacogenetics_based_5-fluorouracil_monitoring_in_colorectal_cancer_patients.pdf application/pdf en http://irep.iium.edu.my/42698/4/42698_METABOLOMICS_scopus.pdf Zakaria, Bannur and Mohd Zaki, Salleh and Hashim, Hazwanie and Tom, Hennessy and Md Nor, Azmi and MH, Zailani and Prabu, Ramasamy and ZA, Zakaria and Suneet, S and Ngow, Harris Abdullah and Henry, Guy M. and Teh, Laykek (2014) Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (Supp 2). pp. 288-295. ISSN 0975-1491 http://www.ijppsjournal.com/contents.htm
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Zakaria, Bannur Mohd Zaki, Salleh Hashim, Hazwanie Tom, Hennessy Md Nor, Azmi MH, Zailani Prabu, Ramasamy ZA, Zakaria Suneet, S Ngow, Harris Abdullah Henry, Guy M. Teh, Laykek Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
description	Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subjects were genotyped for UGT1A128, DPYD 1896 T>C and DPYD5. Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. The predictive PLSDA model revealed 100% accuracy of metabolites differentiating CRC patients and healthy volunteers. In addition, the metabolic profiles associated with different genotypes of DPYD and UGT1A1 explains the impact of genetic variation on differential drug responses. Conclusion: Pharmacogenetics and metabolomics profiles are potential platforms for more comprehensive monitoring of patient's disease progress and drug response. Further study is however needed to validate the use of biomarkers identified. Keywords: Metabolomics, Pharmacogenetics, Polymorphism, Colorectal cancer (CRC), 5-fluorouracil (5-FU)
format	Article
author	Zakaria, Bannur Mohd Zaki, Salleh Hashim, Hazwanie Tom, Hennessy Md Nor, Azmi MH, Zailani Prabu, Ramasamy ZA, Zakaria Suneet, S Ngow, Harris Abdullah Henry, Guy M. Teh, Laykek
author_facet	Zakaria, Bannur Mohd Zaki, Salleh Hashim, Hazwanie Tom, Hennessy Md Nor, Azmi MH, Zailani Prabu, Ramasamy ZA, Zakaria Suneet, S Ngow, Harris Abdullah Henry, Guy M. Teh, Laykek
author_sort	Zakaria, Bannur
title	Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
title_short	Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
title_full	Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
title_fullStr	Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
title_full_unstemmed	Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
title_sort	metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
publisher	International Journal of Pharmacy and Pharmaceutical Sciences ( IJPPS)
publishDate	2014
url	http://irep.iium.edu.my/42698/ http://irep.iium.edu.my/42698/ http://irep.iium.edu.my/42698/1/metabolomics_and_pharmacogenetics_based_5-fluorouracil_monitoring_in_colorectal_cancer_patients.pdf http://irep.iium.edu.my/42698/4/42698_METABOLOMICS_scopus.pdf
first_indexed	2023-09-18T21:00:50Z
last_indexed	2023-09-18T21:00:50Z
_version_	1777410612342554624

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

Similar Items