Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/4276/ http://irep.iium.edu.my/4276/ http://irep.iium.edu.my/4276/1/ADHD.pdf |
| Summary: | Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition
in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive,
inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity
(AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole
and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was
investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities
in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA
is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only
in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen
only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated
with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this
condition. |
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