Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?

Background: Hepatic steatosis and disturbances in lipid metabolism has been identified as one of the metabolic disorders in hepatitis C (HCV) infection. This study was to examine the possible association of steatohepatitis with the degree of fibrosis in chronic HCV patients. Methods: Retrospectiv...

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Main Authors:	Hasmoni, Mohamed Hadzri, Salleh, Rosemi, Jaafar, Khairul Azhar, Jaafar, Mohd. Hanizam, Abas, Ariff
Format:	Article
Language:	English
Published:	Springer 2011
Subjects:	RB Pathology RC Internal medicine
Online Access:	http://irep.iium.edu.my/4311/ http://irep.iium.edu.my/4311/ http://irep.iium.edu.my/4311/1/fulltext.pdf

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recordtype	eprints
spelling	iium-43112011-12-28T23:35:59Z http://irep.iium.edu.my/4311/ Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association? Hasmoni, Mohamed Hadzri Salleh, Rosemi Jaafar, Khairul Azhar Jaafar, Mohd. Hanizam Abas, Ariff RB Pathology RC Internal medicine Background: Hepatic steatosis and disturbances in lipid metabolism has been identified as one of the metabolic disorders in hepatitis C (HCV) infection. This study was to examine the possible association of steatohepatitis with the degree of fibrosis in chronic HCV patients. Methods: Retrospective analysis of data from 72 patients with chronic HCV who underwent liver biopsy from January 2008 to March 2010 in two tertiary hospitals in Malaysia was performed. Patients’ demographic data and their body mass index (BMI), liver function tests and lipid profiles, histological findings of steatosis,staging and grading of biopsy specimen were made. Staging and grading of liver disease was done using modified histological activity index staging (score 0–6) and grading (score 0–18) respectively.Univariate analysis was done to assess the association between the degree of fibrosis and steatohepatitis. Results: 79.2% were males and the mean age for the study population was 40.7 ± 12.0 years. There were 13.9 and 9.7% cases of coinfection with HIV and hepatitis B respectively, while 76.4% patientswere infected with HCV alone. The table showed the superimposed steatohepatitis that was present with severe fibrosis and mild or no fibrosis in the two different groups. However, the univariate analysis assessing the association between the degree of fibrosis and the presence of steatohepatitis in both the two groups could not find any significant result. Conclusion: There was no significant association between steatohepatitis and the degree of fibrosis in patients with chronic HCV infection, either co-infection with other viruses or HCV infection alone. Springer 2011-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/4311/1/fulltext.pdf Hasmoni, Mohamed Hadzri and Salleh, Rosemi and Jaafar, Khairul Azhar and Jaafar, Mohd. Hanizam and Abas, Ariff (2011) Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association? Hepatology International, 5 (1). pp. 312-313. ISSN 1936-0533 http://www.springerlink.com/content/1936-0533
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology RC Internal medicine
spellingShingle	RB Pathology RC Internal medicine Hasmoni, Mohamed Hadzri Salleh, Rosemi Jaafar, Khairul Azhar Jaafar, Mohd. Hanizam Abas, Ariff Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
description	Background: Hepatic steatosis and disturbances in lipid metabolism has been identified as one of the metabolic disorders in hepatitis C (HCV) infection. This study was to examine the possible association of steatohepatitis with the degree of fibrosis in chronic HCV patients. Methods: Retrospective analysis of data from 72 patients with chronic HCV who underwent liver biopsy from January 2008 to March 2010 in two tertiary hospitals in Malaysia was performed. Patients’ demographic data and their body mass index (BMI), liver function tests and lipid profiles, histological findings of steatosis,staging and grading of biopsy specimen were made. Staging and grading of liver disease was done using modified histological activity index staging (score 0–6) and grading (score 0–18) respectively.Univariate analysis was done to assess the association between the degree of fibrosis and steatohepatitis. Results: 79.2% were males and the mean age for the study population was 40.7 ± 12.0 years. There were 13.9 and 9.7% cases of coinfection with HIV and hepatitis B respectively, while 76.4% patientswere infected with HCV alone. The table showed the superimposed steatohepatitis that was present with severe fibrosis and mild or no fibrosis in the two different groups. However, the univariate analysis assessing the association between the degree of fibrosis and the presence of steatohepatitis in both the two groups could not find any significant result. Conclusion: There was no significant association between steatohepatitis and the degree of fibrosis in patients with chronic HCV infection, either co-infection with other viruses or HCV infection alone.
format	Article
author	Hasmoni, Mohamed Hadzri Salleh, Rosemi Jaafar, Khairul Azhar Jaafar, Mohd. Hanizam Abas, Ariff
author_facet	Hasmoni, Mohamed Hadzri Salleh, Rosemi Jaafar, Khairul Azhar Jaafar, Mohd. Hanizam Abas, Ariff
author_sort	Hasmoni, Mohamed Hadzri
title	Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
title_short	Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
title_full	Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
title_fullStr	Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
title_full_unstemmed	Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?
title_sort	steatohepatitis and fibrosis in chronic hepatitis c patients: is there any association?
publisher	Springer
publishDate	2011
url	http://irep.iium.edu.my/4311/ http://irep.iium.edu.my/4311/ http://irep.iium.edu.my/4311/1/fulltext.pdf
first_indexed	2023-09-18T20:12:29Z
last_indexed	2023-09-18T20:12:29Z
_version_	1777407570316623872

Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?

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