Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres

In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience,...

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Main Authors:	Rahman, Md. Mokhlesur, Rezaul Haque, Ansary, Mohamed, Awang, Katas, Haliza
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/43498/ http://irep.iium.edu.my/43498/ http://irep.iium.edu.my/43498/1/43498.pdf

id	iium-43498
recordtype	eprints
spelling	iium-434982018-05-21T02:29:36Z http://irep.iium.edu.my/43498/ Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza QD Chemistry In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience, poly(lactide-co-glycolide) (PLGA) based sustained release formulation of insulin delivery has been developed [2]. Generally, the major drawbacks in the development of insulin loaded PLGA microspheres are the high initial burst and incomplete release of encapsulated insulin [3]. Initial burst release means the release of insulin within 24 hours of release studies. Moreover, PLGA microspheres tend to have a very slow or near to zero release of insulin after the initial burst. The slow or no release period is often referred to as the “lag phase” and continues until extensive degradation of PLGA starts. During this period, the patient may not be effectively treated due to the lack of sufficient insulin release [4]. In this study, insulin encapsulated PLGA microspheres have been prepared using a fast degrading hydroxyl terminated–PLGA (PLGA-OH) to reduce the initial burst release and to remove the lag phase with a view to achieve controlled release of insulin. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/43498/1/43498.pdf Rahman, Md. Mokhlesur and Rezaul Haque, Ansary and Mohamed, Awang and Katas, Haliza (2015) Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres. In: Research Acculturation Collaborative Effort, Colloquim 2015, 13 - 14 January 2015, Barder Enstek, Negeri Sembilan. (Unpublished) http://www.penerbit.upm.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
description	In conventional method, insulin is injected subcutaneously two to four times a day before each meal to maintain the serum glucose level of diabetic patients [1]. This multiple injection routine is complex, painful, inconvenient and fear of hypoglycemia. To improve patient compliance and convenience, poly(lactide-co-glycolide) (PLGA) based sustained release formulation of insulin delivery has been developed [2]. Generally, the major drawbacks in the development of insulin loaded PLGA microspheres are the high initial burst and incomplete release of encapsulated insulin [3]. Initial burst release means the release of insulin within 24 hours of release studies. Moreover, PLGA microspheres tend to have a very slow or near to zero release of insulin after the initial burst. The slow or no release period is often referred to as the “lag phase” and continues until extensive degradation of PLGA starts. During this period, the patient may not be effectively treated due to the lack of sufficient insulin release [4]. In this study, insulin encapsulated PLGA microspheres have been prepared using a fast degrading hydroxyl terminated–PLGA (PLGA-OH) to reduce the initial burst release and to remove the lag phase with a view to achieve controlled release of insulin.
format	Conference or Workshop Item
author	Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza
author_facet	Rahman, Md. Mokhlesur Rezaul Haque, Ansary Mohamed, Awang Katas, Haliza
author_sort	Rahman, Md. Mokhlesur
title	Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
title_short	Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
title_full	Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
title_fullStr	Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
title_full_unstemmed	Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres
title_sort	preparation, characterization and reduction of burst release of insulin from biodegradable plga microspheres
publishDate	2015
url	http://irep.iium.edu.my/43498/ http://irep.iium.edu.my/43498/ http://irep.iium.edu.my/43498/1/43498.pdf
first_indexed	2023-09-18T21:01:58Z
last_indexed	2023-09-18T21:01:58Z
_version_	1777410683690811392

Preparation, characterization and reduction of burst release of insulin from biodegradable PLGA microspheres

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