EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits

OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles. MATERIAL AND METHODS: Sandblasted and cleansed planar titanium specimens with a size of 5 × 5 × 1 mm were coated on one side with 0.25 vol% eicosap...

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Main Authors:	Mustafa, Ammar A., Mustafa, Naziyah Shaban, Mustafa Al-Ahmad, Basma Ezzat, Kashmola, Muhanad Ali Hamdon
Format:	Article
Language:	English English
Published:	Wiley Online Library 2014
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/1/E-proof_Mustafa_et_al_2014_COIR.pdf http://irep.iium.edu.my/43607/2/Twelfth_paper.pdf

id	iium-43607
recordtype	eprints
spelling	iium-436072017-04-13T07:28:33Z http://irep.iium.edu.my/43607/ EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits Mustafa, Ammar A. Mustafa, Naziyah Shaban Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon RK Dentistry OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles. MATERIAL AND METHODS: Sandblasted and cleansed planar titanium specimens with a size of 5 × 5 × 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The other side of the specimens was kept highly polished (the control side). These specimens were inserted in rabbit mandibles. Twelve rabbits were randomly assigned into three study groups (n = 4). The rabbits were sacrificed at 4, 8, and 12 weeks. The harvested specimens with the implants were assessed for new bone formation on both sides of the implant using CBCT, conventional radiographs, and the biaxial pullout test. The results were statistically analyzed by a nonparametric Kruskal-Wallis test and Friedman's test as multiple comparisons and by Brunner-Langer nonparametric mixed model approach (R Software). RESULTS: A significant osteoconductive bone formation was found on the EPA-coated Ti implant surface (P < 0.05) at 8 weeks when compared to the polished surface (control). Biaxial pullout test results showed a significant difference (P < 0.05) after 8 and 12 weeks with a maximum force of 243.8 N, compared to 143.25 N after 4 week. CONCLUSION: EPA implant coating promoted osteoconduction on the Ti implant surfaces, enhancing the anchorage of the implant to the surrounding bone in white New Zealand rabbits. Wiley Online Library 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43607/1/E-proof_Mustafa_et_al_2014_COIR.pdf application/pdf en http://irep.iium.edu.my/43607/2/Twelfth_paper.pdf Mustafa, Ammar A. and Mustafa, Naziyah Shaban and Mustafa Al-Ahmad, Basma Ezzat and Kashmola, Muhanad Ali Hamdon (2014) EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits. Clinical Oral Implants Research, 00. pp. 1-7. ISSN 1600-0501 http://onlinelibrary.wiley.com/doi/10.1111/clr.12525/abstract 10.1111/clr.12525
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry
spellingShingle	RK Dentistry Mustafa, Ammar A. Mustafa, Naziyah Shaban Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
description	OBJECTIVES: To investigate the effect of eicosapentaenoic acid (EPA)-coated Ti implants on osteoconduction in white New Zealand rabbit mandibles. MATERIAL AND METHODS: Sandblasted and cleansed planar titanium specimens with a size of 5 × 5 × 1 mm were coated on one side with 0.25 vol% eicosapentaenoic acid (EPA). The other side of the specimens was kept highly polished (the control side). These specimens were inserted in rabbit mandibles. Twelve rabbits were randomly assigned into three study groups (n = 4). The rabbits were sacrificed at 4, 8, and 12 weeks. The harvested specimens with the implants were assessed for new bone formation on both sides of the implant using CBCT, conventional radiographs, and the biaxial pullout test. The results were statistically analyzed by a nonparametric Kruskal-Wallis test and Friedman's test as multiple comparisons and by Brunner-Langer nonparametric mixed model approach (R Software). RESULTS: A significant osteoconductive bone formation was found on the EPA-coated Ti implant surface (P < 0.05) at 8 weeks when compared to the polished surface (control). Biaxial pullout test results showed a significant difference (P < 0.05) after 8 and 12 weeks with a maximum force of 243.8 N, compared to 143.25 N after 4 week. CONCLUSION: EPA implant coating promoted osteoconduction on the Ti implant surfaces, enhancing the anchorage of the implant to the surrounding bone in white New Zealand rabbits.
format	Article
author	Mustafa, Ammar A. Mustafa, Naziyah Shaban Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon
author_facet	Mustafa, Ammar A. Mustafa, Naziyah Shaban Mustafa Al-Ahmad, Basma Ezzat Kashmola, Muhanad Ali Hamdon
author_sort	Mustafa, Ammar A.
title	EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
title_short	EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
title_full	EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
title_fullStr	EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
title_full_unstemmed	EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits
title_sort	epa-coated titanium implants promote osteoconduction in white new zealand rabbits
publisher	Wiley Online Library
publishDate	2014
url	http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/ http://irep.iium.edu.my/43607/1/E-proof_Mustafa_et_al_2014_COIR.pdf http://irep.iium.edu.my/43607/2/Twelfth_paper.pdf
first_indexed	2023-09-18T21:02:08Z
last_indexed	2023-09-18T21:02:08Z
_version_	1777410693670109184

EPA-coated titanium implants promote osteoconduction in white New Zealand rabbits

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