Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital
Acute kidney injury (AKI) is a common diagnosis among critically ill patients. Although the etiology of AKI will determine the appropriate initial management, the definitive management of established AKI is still debatable. This is a retrospective, observational, single-center analysis of a cohor...
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Saudi Center for Organ Transplantation
2015
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iium-438452017-11-23T08:16:40Z http://irep.iium.edu.my/43845/ Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital Mohd Nor, Fariz Safhan Draman, Che Rosle Seman, Mohd Ramli Abd Manaf, Norasmiza Abd Ghani, Azril Shahreez Hassan, Khairul Anuar RC Internal medicine Acute kidney injury (AKI) is a common diagnosis among critically ill patients. Although the etiology of AKI will determine the appropriate initial management, the definitive management of established AKI is still debatable. This is a retrospective, observational, single-center analysis of a cohort of patients referred to the nephrology unit for AKI from 1st August 2010 to 31st January 2011. Those patients with indications for dialysis were treated with continuous renal replacement therapy, intermittent hemodialysis or stiff-catheter peritoneal dialysis as determined by their hemodynamic status and the technical availability of the method. The 30-day mortality rate, renal outcomes and independent prognostic factors were analyzed statistically. Seventy-five patients were reviewed. The mean age was 52.9 ± 14.5 years. Two-thirds were males and 75% were Malays. 53.3% were referred from intensive wards. Pre-renal AKI and intra-renal AKI were diagnosed in 21.3% and 73.3% patients, respectively. Sepsis was the most common cause (n = 59). The pathogens were successfully cultured in 42.3% of the cases. The median urea and creatinine were 30.4 [interquartile range (IQR) 20.3] mmol/L and 474 (IQR 398.0) µmol/L, respectively. Seventy-six percent had metabolic acidosis. Oliguria was only noted in 38.7% of the patients. Sixty percent (n = 45) of the referrals were treated with conventional, intermittent hemodialysis and 22.7% (n = 17) with continuous veno-venous hemofiltration. The 30-day mortality rate was 28%, and was higher in intensive wards (37.5% versus 17.1%). Thirty-one percent (n = 20) had complete recovery, 17 (26.6%) had partial recovery without dialysis and seven (10.9%) became dialysis dependent. The 30-day mortality rate was 28%. Referral from intensive wards was the only significant poor prognostic factor in our patients and not the dialysis modalities. Saudi Center for Organ Transplantation 2015-07-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/43845/1/SaudiJKidneyDisTranspl264725-7849264_214812.pdf Mohd Nor, Fariz Safhan and Draman, Che Rosle and Seman, Mohd Ramli and Abd Manaf, Norasmiza and Abd Ghani, Azril Shahreez and Hassan, Khairul Anuar (2015) Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital. Saudi Journal of Kidney Diseases and Transplantation, 26 (4). pp. 725-732. ISSN 1319-2442 http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=4;spage=725;epage=732;aulast=Mohd |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RC Internal medicine |
| spellingShingle |
RC Internal medicine Mohd Nor, Fariz Safhan Draman, Che Rosle Seman, Mohd Ramli Abd Manaf, Norasmiza Abd Ghani, Azril Shahreez Hassan, Khairul Anuar Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| description |
Acute kidney injury (AKI) is a common diagnosis among critically ill patients.
Although the etiology of AKI will determine the appropriate initial management, the definitive
management of established AKI is still debatable. This is a retrospective, observational, single-center
analysis of a cohort of patients referred to the nephrology unit for AKI from 1st August 2010 to 31st January 2011. Those patients with indications for dialysis were treated with continuous renal
replacement therapy, intermittent hemodialysis or stiff-catheter peritoneal dialysis as determined by
their hemodynamic status and the technical availability of the method. The 30-day mortality rate, renal
outcomes and independent prognostic factors were analyzed statistically. Seventy-five patients were
reviewed. The mean age was 52.9 ± 14.5 years. Two-thirds were males and 75% were Malays. 53.3%
were referred from intensive wards. Pre-renal AKI and intra-renal AKI were diagnosed in 21.3% and
73.3% patients, respectively. Sepsis was the most common cause (n = 59). The pathogens were
successfully cultured in 42.3% of the cases. The median urea and creatinine were 30.4 [interquartile
range (IQR) 20.3] mmol/L and 474 (IQR 398.0) µmol/L, respectively. Seventy-six percent had
metabolic acidosis. Oliguria was only noted in 38.7% of the patients. Sixty percent (n = 45) of the
referrals were treated with conventional, intermittent hemodialysis and 22.7% (n = 17) with continuous
veno-venous hemofiltration. The 30-day mortality rate was 28%, and was higher in intensive wards
(37.5% versus 17.1%). Thirty-one percent (n = 20) had complete recovery, 17 (26.6%) had partial
recovery without dialysis and seven (10.9%) became dialysis dependent. The 30-day mortality rate
was 28%. Referral from intensive wards was the only significant poor prognostic factor in our patients
and not the dialysis modalities. |
| format |
Article |
| author |
Mohd Nor, Fariz Safhan Draman, Che Rosle Seman, Mohd Ramli Abd Manaf, Norasmiza Abd Ghani, Azril Shahreez Hassan, Khairul Anuar |
| author_facet |
Mohd Nor, Fariz Safhan Draman, Che Rosle Seman, Mohd Ramli Abd Manaf, Norasmiza Abd Ghani, Azril Shahreez Hassan, Khairul Anuar |
| author_sort |
Mohd Nor, Fariz Safhan |
| title |
Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| title_short |
Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| title_full |
Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| title_fullStr |
Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| title_full_unstemmed |
Clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| title_sort |
clinical outcomes of acute kidney injury patients treated in a single-center, sub-urban satellite hospital |
| publisher |
Saudi Center for Organ Transplantation |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/43845/ http://irep.iium.edu.my/43845/ http://irep.iium.edu.my/43845/1/SaudiJKidneyDisTranspl264725-7849264_214812.pdf |
| first_indexed |
2023-09-18T21:02:25Z |
| last_indexed |
2023-09-18T21:02:25Z |
| _version_ |
1777410712137629696 |