Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia

BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 mal...

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Main Authors:	Samsuddin, Niza, Rampal, Krishna Gopal, Ismail, Noor Hassim, Abdullah, Nor Zamzila, Nasreen, Hashima E
Format:	Article
Language:	English English
Published:	Oxford University Press 2015
Subjects:	RA Public aspects of medicine
Online Access:	http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/1/2015_AJHP__PESTICIDES.pdf http://irep.iium.edu.my/44176/4/44176_Pesticides%20exposure%20and%20cardiovascular%20hemodynamic%20parameters%20among%20male%20workers%20involved%20in%20mosquito%20control%20in%20East%20Coast%20of%20Malaysia_SCOPUS.pdf

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spelling	iium-441762017-11-23T07:42:48Z http://irep.iium.edu.my/44176/ Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia Samsuddin, Niza Rampal, Krishna Gopal Ismail, Noor Hassim Abdullah, Nor Zamzila Nasreen, Hashima E RA Public aspects of medicine BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers. Oxford University Press 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44176/1/2015_AJHP__PESTICIDES.pdf application/pdf en http://irep.iium.edu.my/44176/4/44176_Pesticides%20exposure%20and%20cardiovascular%20hemodynamic%20parameters%20among%20male%20workers%20involved%20in%20mosquito%20control%20in%20East%20Coast%20of%20Malaysia_SCOPUS.pdf Samsuddin, Niza and Rampal, Krishna Gopal and Ismail, Noor Hassim and Abdullah, Nor Zamzila and Nasreen, Hashima E (2015) Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia. American Journal of Hypertension, 29. pp. 1-8. ISSN 0895-7061 E-ISSN 1941-7225 http://ajh.oxfordjournals.org/content/early/2015/06/24/ajh.hpv093.abstract 10.1093/ajh/hpv093
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RA Public aspects of medicine
spellingShingle	RA Public aspects of medicine Samsuddin, Niza Rampal, Krishna Gopal Ismail, Noor Hassim Abdullah, Nor Zamzila Nasreen, Hashima E Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
description	BACKGROUND Research findings have linked exposure to pesticides to an increased risk of cardiovascular (CVS) diseases. Therefore, this study aimed to assess the impact of chronic mix-pesticides exposure on CVS hemodynamic parameters. METHODS A total of 198 male Malay pesticide-exposed and 195 male Malay nonexposed workers were examined. Data were collected through exposure-matrix assessment, questionnaire, blood analyses, and CVS assessment. Explanatory variables comprised of lipid profiles, paraoxonase 1 (PON1), and oxidized low-density lipoprotein (ox-LDL). Outcome measures comprised of brachial and aortic diastolic blood pressure (DBP) and systolic BP (SBP), heart rate, and pulse wave velocity (PWV). Linear regressions identified the B coefficient showing how many units of CVS parameters are associated with each unit of covariates. RESULTS Diazoxonase was significantly lower and ox-LDL was higher among pesticide-exposed workers than the comparison group. The final multivariate linear regression model revealed that age, body mass index (BMI), smoking, and pesticide exposure were independent predictors of brachial and aortic DBP and SBP. Pesticide exposure was also associated with heart rate, but not with PWV. Lipid profiles, PON1 enzymes, and ox-LDL showed no association with any of the CVS parameters. CONCLUSIONS Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.
format	Article
author	Samsuddin, Niza Rampal, Krishna Gopal Ismail, Noor Hassim Abdullah, Nor Zamzila Nasreen, Hashima E
author_facet	Samsuddin, Niza Rampal, Krishna Gopal Ismail, Noor Hassim Abdullah, Nor Zamzila Nasreen, Hashima E
author_sort	Samsuddin, Niza
title	Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
title_short	Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
title_full	Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
title_fullStr	Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
title_full_unstemmed	Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia
title_sort	pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in east coast of malaysia
publisher	Oxford University Press
publishDate	2015
url	http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/ http://irep.iium.edu.my/44176/1/2015_AJHP__PESTICIDES.pdf http://irep.iium.edu.my/44176/4/44176_Pesticides%20exposure%20and%20cardiovascular%20hemodynamic%20parameters%20among%20male%20workers%20involved%20in%20mosquito%20control%20in%20East%20Coast%20of%20Malaysia_SCOPUS.pdf
first_indexed	2023-09-18T21:02:50Z
last_indexed	2023-09-18T21:02:50Z
_version_	1777410737713446912

Pesticides exposure and cardiovascular hemodynamic parameters among male workers involved in mosquito control in East Coast of Malaysia

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