Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats

In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically asses...

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Main Authors: Richardson, JD, Bertaso , AG, Frost , L, Psaltis , PJ, Carbone, A, Koschade, B, Wong, DT, Nelson, AJ, Paton, S, Williams, K, Mohd Shah, Azarisman Shah, Worthley, MI, Teo , KS, Gronthos , S, Zannettino, ACW, Worthley, SG
Format: Article
Language:English
Published: SAGE Publications 2013
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http://irep.iium.edu.my/44306/
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http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf
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spelling iium-443062018-06-12T00:53:38Z http://irep.iium.edu.my/44306/ Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats Richardson, JD Bertaso , AG Frost , L Psaltis , PJ Carbone, A Koschade, B Wong, DT Nelson, AJ Paton, S Williams, K Mohd Shah, Azarisman Shah Worthley, MI Teo , KS Gronthos , S Zannettino, ACW Worthley, SG RC Internal medicine In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically assessed these three imaging modalities in determining ejection fraction (EF) in rats. Twenty rats underwent imaging four weeks after surgically-induced myocardial infarction. CMR was performed on a 1.5 T scanner, TTE was conducted using a 9.2 MHz transducer and TOE was performed with a 10 MHz intracardiac echo catheter. Correlation between the three techniques for EF determination and analysis reproducibility was assessed. Moderate-strong correlation was observed between the three modalities; the greatest between CMR and TOE (intraclass correlation coefficient (ICC) = 0.89), followed by TOE and TTE (ICC = 0.70) and CMR and TTE (ICC = 0.63). Intra- and inter-observer variations were excellent with CMR (ICC = 0.99 and 0.98 respectively), very good with TTE (0.90 and 0.89) and TOE (0.87 and 0.84). Each modality is a viable option for evaluating ventricular function in rats, however the high image quality and excellent reproducibility of CMR offers distinct advantages even at 1.5 T with conventional coils and software. KEYWORDS: cardiac magnetic resonance; intracardiac echocardiography; left ventricular function; transoesophageal echocardiography; transthoracic echocardiography SAGE Publications 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf Richardson, JD and Bertaso , AG and Frost , L and Psaltis , PJ and Carbone, A and Koschade, B and Wong, DT and Nelson, AJ and Paton, S and Williams, K and Mohd Shah, Azarisman Shah and Worthley, MI and Teo , KS and Gronthos , S and Zannettino, ACW and Worthley, SG (2013) Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats. Labarotory Animals , 47 (4). pp. 291-300. ISSN 0023-6772 http://lan.sagepub.com/ 23836849
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Richardson, JD
Bertaso , AG
Frost , L
Psaltis , PJ
Carbone, A
Koschade, B
Wong, DT
Nelson, AJ
Paton, S
Williams, K
Mohd Shah, Azarisman Shah
Worthley, MI
Teo , KS
Gronthos , S
Zannettino, ACW
Worthley, SG
Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
description In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically assessed these three imaging modalities in determining ejection fraction (EF) in rats. Twenty rats underwent imaging four weeks after surgically-induced myocardial infarction. CMR was performed on a 1.5 T scanner, TTE was conducted using a 9.2 MHz transducer and TOE was performed with a 10 MHz intracardiac echo catheter. Correlation between the three techniques for EF determination and analysis reproducibility was assessed. Moderate-strong correlation was observed between the three modalities; the greatest between CMR and TOE (intraclass correlation coefficient (ICC) = 0.89), followed by TOE and TTE (ICC = 0.70) and CMR and TTE (ICC = 0.63). Intra- and inter-observer variations were excellent with CMR (ICC = 0.99 and 0.98 respectively), very good with TTE (0.90 and 0.89) and TOE (0.87 and 0.84). Each modality is a viable option for evaluating ventricular function in rats, however the high image quality and excellent reproducibility of CMR offers distinct advantages even at 1.5 T with conventional coils and software. KEYWORDS: cardiac magnetic resonance; intracardiac echocardiography; left ventricular function; transoesophageal echocardiography; transthoracic echocardiography
format Article
author Richardson, JD
Bertaso , AG
Frost , L
Psaltis , PJ
Carbone, A
Koschade, B
Wong, DT
Nelson, AJ
Paton, S
Williams, K
Mohd Shah, Azarisman Shah
Worthley, MI
Teo , KS
Gronthos , S
Zannettino, ACW
Worthley, SG
author_facet Richardson, JD
Bertaso , AG
Frost , L
Psaltis , PJ
Carbone, A
Koschade, B
Wong, DT
Nelson, AJ
Paton, S
Williams, K
Mohd Shah, Azarisman Shah
Worthley, MI
Teo , KS
Gronthos , S
Zannettino, ACW
Worthley, SG
author_sort Richardson, JD
title Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_short Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_full Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_fullStr Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_full_unstemmed Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_sort cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
publisher SAGE Publications
publishDate 2013
url http://irep.iium.edu.my/44306/
http://irep.iium.edu.my/44306/
http://irep.iium.edu.my/44306/
http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf
first_indexed 2023-09-18T21:03:00Z
last_indexed 2023-09-18T21:03:00Z
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