Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats

In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically asses...

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Main Authors:	Richardson, JD, Bertaso , AG, Frost , L, Psaltis , PJ, Carbone, A, Koschade, B, Wong, DT, Nelson, AJ, Paton, S, Williams, K, Mohd Shah, Azarisman Shah, Worthley, MI, Teo , KS, Gronthos , S, Zannettino, ACW, Worthley, SG
Format:	Article
Language:	English
Published:	SAGE Publications 2013
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf

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spelling	iium-443062018-06-12T00:53:38Z http://irep.iium.edu.my/44306/ Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats Richardson, JD Bertaso , AG Frost , L Psaltis , PJ Carbone, A Koschade, B Wong, DT Nelson, AJ Paton, S Williams, K Mohd Shah, Azarisman Shah Worthley, MI Teo , KS Gronthos , S Zannettino, ACW Worthley, SG RC Internal medicine In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically assessed these three imaging modalities in determining ejection fraction (EF) in rats. Twenty rats underwent imaging four weeks after surgically-induced myocardial infarction. CMR was performed on a 1.5 T scanner, TTE was conducted using a 9.2 MHz transducer and TOE was performed with a 10 MHz intracardiac echo catheter. Correlation between the three techniques for EF determination and analysis reproducibility was assessed. Moderate-strong correlation was observed between the three modalities; the greatest between CMR and TOE (intraclass correlation coefficient (ICC) = 0.89), followed by TOE and TTE (ICC = 0.70) and CMR and TTE (ICC = 0.63). Intra- and inter-observer variations were excellent with CMR (ICC = 0.99 and 0.98 respectively), very good with TTE (0.90 and 0.89) and TOE (0.87 and 0.84). Each modality is a viable option for evaluating ventricular function in rats, however the high image quality and excellent reproducibility of CMR offers distinct advantages even at 1.5 T with conventional coils and software. KEYWORDS: cardiac magnetic resonance; intracardiac echocardiography; left ventricular function; transoesophageal echocardiography; transthoracic echocardiography SAGE Publications 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf Richardson, JD and Bertaso , AG and Frost , L and Psaltis , PJ and Carbone, A and Koschade, B and Wong, DT and Nelson, AJ and Paton, S and Williams, K and Mohd Shah, Azarisman Shah and Worthley, MI and Teo , KS and Gronthos , S and Zannettino, ACW and Worthley, SG (2013) Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats. Labarotory Animals , 47 (4). pp. 291-300. ISSN 0023-6772 http://lan.sagepub.com/ 23836849
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Richardson, JD Bertaso , AG Frost , L Psaltis , PJ Carbone, A Koschade, B Wong, DT Nelson, AJ Paton, S Williams, K Mohd Shah, Azarisman Shah Worthley, MI Teo , KS Gronthos , S Zannettino, ACW Worthley, SG Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
description	In vivo assessment of ventricular function in rodents has largely been restricted to transthoracic echocardiography (TTE). However 1.5 T cardiac magnetic resonance (CMR) and transoesophageal echocardiography (TOE) have emerged as possible alternatives. Yet, to date, no study has systematically assessed these three imaging modalities in determining ejection fraction (EF) in rats. Twenty rats underwent imaging four weeks after surgically-induced myocardial infarction. CMR was performed on a 1.5 T scanner, TTE was conducted using a 9.2 MHz transducer and TOE was performed with a 10 MHz intracardiac echo catheter. Correlation between the three techniques for EF determination and analysis reproducibility was assessed. Moderate-strong correlation was observed between the three modalities; the greatest between CMR and TOE (intraclass correlation coefficient (ICC) = 0.89), followed by TOE and TTE (ICC = 0.70) and CMR and TTE (ICC = 0.63). Intra- and inter-observer variations were excellent with CMR (ICC = 0.99 and 0.98 respectively), very good with TTE (0.90 and 0.89) and TOE (0.87 and 0.84). Each modality is a viable option for evaluating ventricular function in rats, however the high image quality and excellent reproducibility of CMR offers distinct advantages even at 1.5 T with conventional coils and software. KEYWORDS: cardiac magnetic resonance; intracardiac echocardiography; left ventricular function; transoesophageal echocardiography; transthoracic echocardiography
format	Article
author	Richardson, JD Bertaso , AG Frost , L Psaltis , PJ Carbone, A Koschade, B Wong, DT Nelson, AJ Paton, S Williams, K Mohd Shah, Azarisman Shah Worthley, MI Teo , KS Gronthos , S Zannettino, ACW Worthley, SG
author_facet	Richardson, JD Bertaso , AG Frost , L Psaltis , PJ Carbone, A Koschade, B Wong, DT Nelson, AJ Paton, S Williams, K Mohd Shah, Azarisman Shah Worthley, MI Teo , KS Gronthos , S Zannettino, ACW Worthley, SG
author_sort	Richardson, JD
title	Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_short	Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_full	Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_fullStr	Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_full_unstemmed	Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
title_sort	cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
publisher	SAGE Publications
publishDate	2013
url	http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/ http://irep.iium.edu.my/44306/1/a8._LabAnim_2013%3B_47%284%29_291-300_TTE_TOE_CMR_Comparison_for_LVEF_C.pdf
first_indexed	2023-09-18T21:03:00Z
last_indexed	2023-09-18T21:03:00Z
_version_	1777410748597665792

Cardiac magnetic resonance, transthoracic and trans oesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats

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