Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals
Objective To verify possible relations between 5ʹ-nucleotidase, xanthine oxidase to E3 small ubiquitin-like modifier-protein ligase non structural maintenance of chromosomes elements 2 in sera patients with kidney stones and to evaluate the possibility of a new biomarker for the evaluation of kid...
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Asian Pacific Journal of Tropical Biomedicine
2015
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| Online Access: | http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/1/P_63.pdf |
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iium-444632019-03-07T03:10:36Z http://irep.iium.edu.my/44463/ Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ghazali, Hamid Abd Rahman, Azlina R Medicine (General) Objective To verify possible relations between 5ʹ-nucleotidase, xanthine oxidase to E3 small ubiquitin-like modifier-protein ligase non structural maintenance of chromosomes elements 2 in sera patients with kidney stones and to evaluate the possibility of a new biomarker for the evaluation of kidney damage. Methods A sixty patients with known kidney stones who appeared the government health clinics in Kuantan–Pahang and fifty apparently healthy were taken as control group. The 5ʹ-nucleotidase, xanthine oxidase and other biochemical parameters were measured by colorimetric tests. The serum NSMCE2 were measured by enzyme linked immunosorbent assay. Results The mean serum xanthine oxidase [(39.98 ± 19.70) IU/L] and ecto-5ʹ-nucleotidase activity (40.03 ± 9.53 IU/L) were significantly higher than the controls' levels of (18.04 ± 6.26) and (16.06 ± 4.61) IU/L respectively. There were 85.00% and 83.33%, of patients with kidney stones who had abnormal ecto-5ʹ-nucleotidase activity and uric acid respectively while xanthine oxidase activity was less sensitive 58.33%. Conclusions The present study suggests that the increase in serum of xanthine oxidase,ecto-5ʹ-nucleotidase activities E3 small ubiquitin-like modifier-protein ligase NSE2 concentration can be used as biomarkers for diagnosis of kidney damage in patients with kidney stone, also in developments of change DNA damage and inflammation disorders in these patients. Asian Pacific Journal of Tropical Biomedicine 2015-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44463/1/P_63.pdf Yusof, Faridah and Mehde, Atheer Awad and Mehdi, Wesen Adel and Ghazali, Hamid and Abd Rahman, Azlina (2015) Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals. Asian Pacific Journal of Tropical Biomedicine, 5 (8). pp. 665-668. ISSN 2221 1691 http://www.sciencedirect.com/science/article/pii/S2221169115001112 10.1016/j.apjtb.2015.05.013, Elsevier. |
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Digital Repository |
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Local University |
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International Islamic University Malaysia |
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IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ghazali, Hamid Abd Rahman, Azlina Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| description |
Objective
To verify possible relations between 5ʹ-nucleotidase, xanthine oxidase to E3 small ubiquitin-like modifier-protein ligase non structural maintenance of chromosomes elements 2 in sera patients with kidney stones and to evaluate the possibility of a new biomarker for the evaluation of kidney damage.
Methods
A sixty patients with known kidney stones who appeared the government health clinics in Kuantan–Pahang and fifty apparently healthy were taken as control group. The 5ʹ-nucleotidase, xanthine oxidase and other biochemical parameters were measured by colorimetric tests. The serum NSMCE2 were measured by enzyme linked immunosorbent assay.
Results
The mean serum xanthine oxidase [(39.98 ± 19.70) IU/L] and ecto-5ʹ-nucleotidase activity (40.03 ± 9.53 IU/L) were significantly higher than the controls' levels of (18.04 ± 6.26) and (16.06 ± 4.61) IU/L respectively. There were 85.00% and 83.33%, of patients with kidney stones who had abnormal ecto-5ʹ-nucleotidase activity and uric acid respectively while xanthine oxidase activity was less sensitive 58.33%.
Conclusions
The present study suggests that the increase in serum of xanthine oxidase,ecto-5ʹ-nucleotidase activities E3 small ubiquitin-like modifier-protein ligase NSE2 concentration can be used as biomarkers for diagnosis of kidney damage in patients with kidney stone, also in developments of change DNA damage and inflammation disorders in these patients. |
| format |
Article |
| author |
Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ghazali, Hamid Abd Rahman, Azlina |
| author_facet |
Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ghazali, Hamid Abd Rahman, Azlina |
| author_sort |
Yusof, Faridah |
| title |
Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| title_short |
Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| title_full |
Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| title_fullStr |
Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| title_full_unstemmed |
Study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (NSMCE2) in Malaysian individuals |
| title_sort |
study the effect of kidney stones on serum xanthine oxidase, ecto-5’-nucleotidase activity and e3 sumo-protein ligase nse2 (nsmce2) in malaysian individuals |
| publisher |
Asian Pacific Journal of Tropical Biomedicine |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/ http://irep.iium.edu.my/44463/1/P_63.pdf |
| first_indexed |
2023-09-18T21:03:13Z |
| last_indexed |
2023-09-18T21:03:13Z |
| _version_ |
1777410761824403456 |