Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres

Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres

The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA micro...

Full description

Bibliographic Details
Main Authors: Rahman, Md. Mokhlesur, Ansary, Rezaul Haque, Katas, Haliza, Ab. Hadi, Hazrina, Mohamed, Awang
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/44964/
http://irep.iium.edu.my/44964/
http://irep.iium.edu.my/44964/1/44964_abstract.pdf
id iium-44964
recordtype eprints
spelling iium-449642017-10-12T02:37:49Z http://irep.iium.edu.my/44964/ Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres Rahman, Md. Mokhlesur Ansary, Rezaul Haque Katas, Haliza Ab. Hadi, Hazrina Mohamed, Awang QD Chemistry The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA microspheres. Double-walled microspheres were prepared by a modified water-in-oil-in-oil-in-water (w/o/o/w) emulsion solvent evaporation method. The prepared double-walled microspheres were non-porous, smooth surfaced, and spherical in shape. A significant reduction of the initial burst release of insulin was achieved from the prepared double-walled microspheres. Moreover, a sustained and complete release of insulin without any lag phase was achieved in this study. Thus, double-walled microspheres can be a potential delivery system of therapeutic insulin. 2015-12-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/44964/1/44964_abstract.pdf Rahman, Md. Mokhlesur and Ansary, Rezaul Haque and Katas, Haliza and Ab. Hadi, Hazrina and Mohamed, Awang (2015) Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres. In: Controlled Release & Drug Delivery Symposium 2014 (CRDDS 2015), 23rd-24th Aug. 2015, Kuala Lumpur Campus, Kuala Lumpur. (Unpublished) http://www.ukm.my/crdds/index.php/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Rahman, Md. Mokhlesur
Ansary, Rezaul Haque
Katas, Haliza
Ab. Hadi, Hazrina
Mohamed, Awang
Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
description The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA microspheres. Double-walled microspheres were prepared by a modified water-in-oil-in-oil-in-water (w/o/o/w) emulsion solvent evaporation method. The prepared double-walled microspheres were non-porous, smooth surfaced, and spherical in shape. A significant reduction of the initial burst release of insulin was achieved from the prepared double-walled microspheres. Moreover, a sustained and complete release of insulin without any lag phase was achieved in this study. Thus, double-walled microspheres can be a potential delivery system of therapeutic insulin.
format Conference or Workshop Item
author Rahman, Md. Mokhlesur
Ansary, Rezaul Haque
Katas, Haliza
Ab. Hadi, Hazrina
Mohamed, Awang
author_facet Rahman, Md. Mokhlesur
Ansary, Rezaul Haque
Katas, Haliza
Ab. Hadi, Hazrina
Mohamed, Awang
author_sort Rahman, Md. Mokhlesur
title Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
title_short Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
title_full Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
title_fullStr Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
title_full_unstemmed Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
title_sort preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
publishDate 2015
url http://irep.iium.edu.my/44964/
http://irep.iium.edu.my/44964/
http://irep.iium.edu.my/44964/1/44964_abstract.pdf
first_indexed 2023-09-18T21:03:57Z
last_indexed 2023-09-18T21:03:57Z
_version_ 1777410807814946816

Similar Items