Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products

This study aimed to formulate and characterize betamethasone 17-valerate creams produced from palm olein-based oil-in-water emulsions and compare the data to that of commercial products. Test creams with three different viscosities were prepared using varying concentrations (0.1, 0.2 and 0.3% w/w) o...

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Main Authors:	Win, Thazin, Ahmad, Kausar, Md. Jaffri, Juliana, Edueng, Khadijah
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/44983/ http://irep.iium.edu.my/44983/1/Conference_PHARMATECH2014_Betamethasone_kausar20151007.pdf

id	iium-44983
recordtype	eprints
spelling	iium-449832015-11-19T01:00:15Z http://irep.iium.edu.my/44983/ Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah QD Chemistry RS Pharmacy and materia medica This study aimed to formulate and characterize betamethasone 17-valerate creams produced from palm olein-based oil-in-water emulsions and compare the data to that of commercial products. Test creams with three different viscosities were prepared using varying concentrations (0.1, 0.2 and 0.3% w/w) of Carbopol®940 as thickener, palm olein as oil phase, Span®20/Tween®20 as surfactants, parabens and chlorocresol as preservatives, propylene glycol as solubilizer, betamethasone 17-valerate as active ingredient and distilled water as aqueous phase. Control creams were prepared without drug to investigate the effect of the drug on vehicle. Three marketed creams containing same active ingredient were purchased from local pharmacy for comparison purpose. All formulations were characterized for particle size, viscosity, rheology, phase separation, pH and zeta-potential for one year. Statistical analysis was performed with MINITAB® (version 16.1) software. The optimized formulations showed particle size range 2 to 14 μm, viscosity 100 ± 0.57 mPa.s, yield stress 35.6 ± 4.6 Pa, thixotropy 789 ± 1.15, pH 5.0 ± 0.2 and zeta potential -68.36 ± 1.06 mV. In comparison, the commercial creams had larger particle sizes and slightly higher viscosities. However, test creams had greater electrophoretic stabilities than marketed creams as the latter had lower zeta potential values (13.02 ± 0.78 mV). Moreover, betamethasone 17-valerate did not affect the properties of vehicle as the results of control creams were not greatly different from that of test creams. From these results, it was concluded that palm-olein-in-water emulsion could be alternative vehicle for topical drug delivery of lipophilic drugs. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/44983/1/Conference_PHARMATECH2014_Betamethasone_kausar20151007.pdf Win, Thazin and Ahmad, Kausar and Md. Jaffri, Juliana and Edueng, Khadijah (2014) Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products. In: PharmaTech 2014, 3rd International Conference and Exhibition on Pharmaceutical, Nutraceutical and Cosmeceutical Technology, 1st-2nd Dec. 2014, Queen Sirikit National Convention Center, Bangkok, Thailand.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry RS Pharmacy and materia medica Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
description	This study aimed to formulate and characterize betamethasone 17-valerate creams produced from palm olein-based oil-in-water emulsions and compare the data to that of commercial products. Test creams with three different viscosities were prepared using varying concentrations (0.1, 0.2 and 0.3% w/w) of Carbopol®940 as thickener, palm olein as oil phase, Span®20/Tween®20 as surfactants, parabens and chlorocresol as preservatives, propylene glycol as solubilizer, betamethasone 17-valerate as active ingredient and distilled water as aqueous phase. Control creams were prepared without drug to investigate the effect of the drug on vehicle. Three marketed creams containing same active ingredient were purchased from local pharmacy for comparison purpose. All formulations were characterized for particle size, viscosity, rheology, phase separation, pH and zeta-potential for one year. Statistical analysis was performed with MINITAB® (version 16.1) software. The optimized formulations showed particle size range 2 to 14 μm, viscosity 100 ± 0.57 mPa.s, yield stress 35.6 ± 4.6 Pa, thixotropy 789 ± 1.15, pH 5.0 ± 0.2 and zeta potential -68.36 ± 1.06 mV. In comparison, the commercial creams had larger particle sizes and slightly higher viscosities. However, test creams had greater electrophoretic stabilities than marketed creams as the latter had lower zeta potential values (13.02 ± 0.78 mV). Moreover, betamethasone 17-valerate did not affect the properties of vehicle as the results of control creams were not greatly different from that of test creams. From these results, it was concluded that palm-olein-in-water emulsion could be alternative vehicle for topical drug delivery of lipophilic drugs.
format	Conference or Workshop Item
author	Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah
author_facet	Win, Thazin Ahmad, Kausar Md. Jaffri, Juliana Edueng, Khadijah
author_sort	Win, Thazin
title	Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
title_short	Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
title_full	Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
title_fullStr	Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
title_full_unstemmed	Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
title_sort	formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products
publishDate	2014
url	http://irep.iium.edu.my/44983/ http://irep.iium.edu.my/44983/1/Conference_PHARMATECH2014_Betamethasone_kausar20151007.pdf
first_indexed	2023-09-18T21:03:58Z
last_indexed	2023-09-18T21:03:58Z
_version_	1777410809778929664

Formulation and characterization of palm oil ester-based betamethasone 17-valerate creams and comparison with marketed products

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