An empirical assessment of meta-analysis estimates from multi-level studies

A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the ove...

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Main Authors:	Misran, Nurul Afiqah, Nik Idris, Nik Ruzni
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/1/IREP.pdf http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf

id	iium-45232
recordtype	eprints
spelling	iium-452322016-05-23T02:05:49Z http://irep.iium.edu.my/45232/ An empirical assessment of meta-analysis estimates from multi-level studies Misran, Nurul Afiqah Nik Idris, Nik Ruzni Q Science (General) A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the overall estimates have not been fully explored. Objective: This study examined the efficacy of the estimates of overall treatment effect from AD, IPD and the mixed AD: IPD studies, and investigated how they differ from the true treatment effect. Additionally, this study investigated the influence of the ratio of AD: IPD on the precision of the overall treatment effects estimates. The bias, root mean-square-error (RMSE) and coverage probability were used to assess the efficiency of the overall estimates. Results: The results showed that the IPD meta-analysis produced better estimates in terms of RMSE compared to AD meta-analysis and the mixed AD:IPD meta-analysis. For the cases where both the AD and IPD studies were available, our findings showed that the combined AD : IPD data produced better estimates, in terms of precision, than utilising the AD alone. Conclusion: It is therefore recommended that available IPD should always be included in a conventional meta-analysis using summary level data as significant 2015-10-15 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/45232/1/IREP.pdf application/pdf en http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf Misran, Nurul Afiqah and Nik Idris, Nik Ruzni (2015) An empirical assessment of meta-analysis estimates from multi-level studies. In: National Postgraduate Conference on Science and Technology (NPCST 2015), 9-10 Oct 2015, Melia Hotel, Kuala Lumpur. http://npcst2015.weebly.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Misran, Nurul Afiqah Nik Idris, Nik Ruzni An empirical assessment of meta-analysis estimates from multi-level studies
description	A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the overall estimates have not been fully explored. Objective: This study examined the efficacy of the estimates of overall treatment effect from AD, IPD and the mixed AD: IPD studies, and investigated how they differ from the true treatment effect. Additionally, this study investigated the influence of the ratio of AD: IPD on the precision of the overall treatment effects estimates. The bias, root mean-square-error (RMSE) and coverage probability were used to assess the efficiency of the overall estimates. Results: The results showed that the IPD meta-analysis produced better estimates in terms of RMSE compared to AD meta-analysis and the mixed AD:IPD meta-analysis. For the cases where both the AD and IPD studies were available, our findings showed that the combined AD : IPD data produced better estimates, in terms of precision, than utilising the AD alone. Conclusion: It is therefore recommended that available IPD should always be included in a conventional meta-analysis using summary level data as significant
format	Conference or Workshop Item
author	Misran, Nurul Afiqah Nik Idris, Nik Ruzni
author_facet	Misran, Nurul Afiqah Nik Idris, Nik Ruzni
author_sort	Misran, Nurul Afiqah
title	An empirical assessment of meta-analysis estimates from multi-level studies
title_short	An empirical assessment of meta-analysis estimates from multi-level studies
title_full	An empirical assessment of meta-analysis estimates from multi-level studies
title_fullStr	An empirical assessment of meta-analysis estimates from multi-level studies
title_full_unstemmed	An empirical assessment of meta-analysis estimates from multi-level studies
title_sort	empirical assessment of meta-analysis estimates from multi-level studies
publishDate	2015
url	http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/1/IREP.pdf http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf
first_indexed	2023-09-18T21:04:22Z
last_indexed	2023-09-18T21:04:22Z
_version_	1777410834962579456

An empirical assessment of meta-analysis estimates from multi-level studies

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