A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis

The objective of this study is to ascertain the efficacy of the existing two-stage method for combining the Aggregate Data (AD) and Individual Patient Data (IPD) studies in meta-analysis and to introduce some modifications to the existing two-stage method for combining the these studies. We evaluat...

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Main Authors:	Nik Idris, Nik Ruzni, Misran, Nurul Afiqah
Format:	Article
Language:	English
Published:	Asian Network for Scientific Information 2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/1/Published_paper.pdf

id	iium-45254
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spelling	iium-452542017-10-26T08:25:27Z http://irep.iium.edu.my/45254/ A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis Nik Idris, Nik Ruzni Misran, Nurul Afiqah Q Science (General) The objective of this study is to ascertain the efficacy of the existing two-stage method for combining the Aggregate Data (AD) and Individual Patient Data (IPD) studies in meta-analysis and to introduce some modifications to the existing two-stage method for combining the these studies. We evaluated the effects of these modifications on the estimates of the overall treatment effect and investigated the influence of the number of studies included in the meta-analysis, N and the ratio of AD: IPD on these estimates. We used Percentage Relative Bias (PRB), Root Mean Square Error (RMSE) and coverage probability to assess the overall efficiency of these estimates. The results revealed that the current method for combining the AD:IPD studies exhibit rather poor coverage probability. We showed that the proposed methods had been able to improve the coverage probability by more than 40%, while maintaining the level of bias at par to their existing counterparts. These findings demonstrated the significance of proper technique for combining these studies in order to obtain better overall estimates, which is crucial for reliable overall conclusions. Asian Network for Scientific Information 2015-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45254/1/Published_paper.pdf Nik Idris, Nik Ruzni and Misran, Nurul Afiqah (2015) A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis. Journal of Applied Sciences, 15 (10). pp. 1231-1238. ISSN 1812-5662 (O), 1812-5654 (P) http://docsdrive.com/pdfs/ansinet/jas/2015/1231-1238.pdf 10.3923/jas.2015.1231.1238
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Nik Idris, Nik Ruzni Misran, Nurul Afiqah A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
description	The objective of this study is to ascertain the efficacy of the existing two-stage method for combining the Aggregate Data (AD) and Individual Patient Data (IPD) studies in meta-analysis and to introduce some modifications to the existing two-stage method for combining the these studies. We evaluated the effects of these modifications on the estimates of the overall treatment effect and investigated the influence of the number of studies included in the meta-analysis, N and the ratio of AD: IPD on these estimates. We used Percentage Relative Bias (PRB), Root Mean Square Error (RMSE) and coverage probability to assess the overall efficiency of these estimates. The results revealed that the current method for combining the AD:IPD studies exhibit rather poor coverage probability. We showed that the proposed methods had been able to improve the coverage probability by more than 40%, while maintaining the level of bias at par to their existing counterparts. These findings demonstrated the significance of proper technique for combining these studies in order to obtain better overall estimates, which is crucial for reliable overall conclusions.
format	Article
author	Nik Idris, Nik Ruzni Misran, Nurul Afiqah
author_facet	Nik Idris, Nik Ruzni Misran, Nurul Afiqah
author_sort	Nik Idris, Nik Ruzni
title	A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
title_short	A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
title_full	A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
title_fullStr	A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
title_full_unstemmed	A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
title_sort	modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis
publisher	Asian Network for Scientific Information
publishDate	2015
url	http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/ http://irep.iium.edu.my/45254/1/Published_paper.pdf
first_indexed	2023-09-18T21:04:25Z
last_indexed	2023-09-18T21:04:25Z
_version_	1777410837425684480

A modified two-stage method for combining the aggregate-data and individual-patient-data in meta-analysis

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