Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats

Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure...

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Main Authors:	Mohd Noor, Noriah, Aminuddin, Niferiti, Tin, Myo Han, Mohd Rashid, Muhammad Hakimi, Abdul Razak, Tariq
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/45310/ http://irep.iium.edu.my/45310/ http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf

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recordtype	eprints
spelling	iium-453102016-05-24T00:23:16Z http://irep.iium.edu.my/45310/ Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats Mohd Noor, Noriah Aminuddin, Niferiti Tin, Myo Han Mohd Rashid, Muhammad Hakimi Abdul Razak, Tariq R Medicine (General) Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure (SBP) at third week of gestation as compared to pre-pregnancy SBP. Methodology: 30 female Sprague Dawley normotensive rats were randomly assigned into three groups based on maternal dietary salt concentration; low salt (0.145% NaCl, n=10), normal salt (1.0% NaCl, n =10) and high salt (3.0% NaCl, n=10). Food intake and maternal body weight were recorded. SBP (mmHg) and heart rate (HR) were measured during pre-pregnancy and at third week of pregnancy by using non-invasive tail cuff blood pressure monitoring device. Results: There were comparable pre-pregnancy body weight, mean daily food intake, HR and SBP (116.5± 1.54 vs. 118.07 ± 1.22 vs. 115.83 ± 1.76) among LSD, NSD and HSD dams respectively. There were no significant differences in maternal mean daily food intake throughout the pregnancy, body weight at third week of gestation, HR and SBP (113.67± 2.74 vs. 111.37 ± 1.84 vs. 113.93 ± 2.11) at third week of gestation among LSD, NSD and HSD dams respectively. Statistically significant difference in term of SBP between pre-pregnancy and third week of gestation was only seen in the NSD dams (118.07 ±1.22 vs. 111.37 ±1.84) (P<0.05). HR was comparable among the three dams. Conclusion: The SBP decreases in all maternal groups at third week of gestation. However, within group analysis revealed that only NSD dams has significantly lower SBP at third week of gestation as compared to pre- pregnancy SBP. The decrement of SBP is more pronounced in the NSD dams depicting the possibilities of aberration in the expected cardiovascular physiological changes in LSD and HSD dams. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf Mohd Noor, Noriah and Aminuddin, Niferiti and Tin, Myo Han and Mohd Rashid, Muhammad Hakimi and Abdul Razak, Tariq (2015) Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats. In: USIM International Conference on Medicine and Health, 17-18 Oct 2015, Nilai, Negeri Sembilan. http://icmh2015.usim.edu.my/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohd Noor, Noriah Aminuddin, Niferiti Tin, Myo Han Mohd Rashid, Muhammad Hakimi Abdul Razak, Tariq Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
description	Background: Current evidence indicates mixed findings with regard to the effects of low and high maternal dietary salt intake during pregnancy on the maternal blood pressure. Objective: This study investigates the effects of low and high maternal dietary salt intake on the systolic blood pressure (SBP) at third week of gestation as compared to pre-pregnancy SBP. Methodology: 30 female Sprague Dawley normotensive rats were randomly assigned into three groups based on maternal dietary salt concentration; low salt (0.145% NaCl, n=10), normal salt (1.0% NaCl, n =10) and high salt (3.0% NaCl, n=10). Food intake and maternal body weight were recorded. SBP (mmHg) and heart rate (HR) were measured during pre-pregnancy and at third week of pregnancy by using non-invasive tail cuff blood pressure monitoring device. Results: There were comparable pre-pregnancy body weight, mean daily food intake, HR and SBP (116.5± 1.54 vs. 118.07 ± 1.22 vs. 115.83 ± 1.76) among LSD, NSD and HSD dams respectively. There were no significant differences in maternal mean daily food intake throughout the pregnancy, body weight at third week of gestation, HR and SBP (113.67± 2.74 vs. 111.37 ± 1.84 vs. 113.93 ± 2.11) at third week of gestation among LSD, NSD and HSD dams respectively. Statistically significant difference in term of SBP between pre-pregnancy and third week of gestation was only seen in the NSD dams (118.07 ±1.22 vs. 111.37 ±1.84) (P<0.05). HR was comparable among the three dams. Conclusion: The SBP decreases in all maternal groups at third week of gestation. However, within group analysis revealed that only NSD dams has significantly lower SBP at third week of gestation as compared to pre- pregnancy SBP. The decrement of SBP is more pronounced in the NSD dams depicting the possibilities of aberration in the expected cardiovascular physiological changes in LSD and HSD dams.
format	Conference or Workshop Item
author	Mohd Noor, Noriah Aminuddin, Niferiti Tin, Myo Han Mohd Rashid, Muhammad Hakimi Abdul Razak, Tariq
author_facet	Mohd Noor, Noriah Aminuddin, Niferiti Tin, Myo Han Mohd Rashid, Muhammad Hakimi Abdul Razak, Tariq
author_sort	Mohd Noor, Noriah
title	Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_short	Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_full	Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_fullStr	Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_full_unstemmed	Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
title_sort	maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats
publishDate	2015
url	http://irep.iium.edu.my/45310/ http://irep.iium.edu.my/45310/ http://irep.iium.edu.my/45310/1/Noriah_et_al_2015.pdf
first_indexed	2023-09-18T21:04:30Z
last_indexed	2023-09-18T21:04:30Z
_version_	1777410843110014976

Maternal blood pressure during gestation: the effects of low and high salt intake during pregnancy in normotensive sprague dawley rats

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