Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo
Production of ATP by the glycolytic pathway in the mammalian pathogenic stage of protists from the genus Trypanosoma is required for the survival of the parasites. Cofactor-independent phosphoglycerate mutase (iPGAM) is particularly attractive as a drug target because it shows no similarity to the...
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| Format: | Article |
| Language: | English |
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Royal Society of Chemistry
2011
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| Online Access: | http://irep.iium.edu.my/45464/ http://irep.iium.edu.my/45464/ http://irep.iium.edu.my/45464/1/%2BFuad_et_al._2011.pdf |