Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surfa...

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Main Authors:	Senjoti, Faria Gias, Mahmood, Syed, Md. Jaffri, Juliana, Mandal, Uttam Kumar
Format:	Article
Language:	English English
Published:	School of Pharmacy, Shahid Beheshti University of Medical Sciences 2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/45505/ http://irep.iium.edu.my/45505/ http://irep.iium.edu.my/45505/3/Published_article_in_press.pdf http://irep.iium.edu.my/45505/4/Proof_Articles_in_Press.pdf

id	iium-45505
recordtype	eprints
spelling	iium-455052018-06-25T04:26:44Z http://irep.iium.edu.my/45505/ Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling Senjoti, Faria Gias Mahmood, Syed Md. Jaffri, Juliana Mandal, Uttam Kumar RS Pharmacy and materia medica An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken design of experiment where polymer content of HPMC and PEO at 1: 4 ratio (A), amount of sodium bi-carbonate (B), and amount of SSG (C) were adopted as independent variables. Floating lag time in sec (Y1), cumulative percent drug released at 1 h (Y2) and 12 h (Y3) were chosen as response variables. Tablets from the optimized formulation were also stored at accelerated stability condition (40°C and 75% RH) for 3 months to assess their stability profile. RSM could efficiently optimize the tablet composition with excellent prediction ability. In-vitro drug release until 12 h, floating lag time, and duration of floating were dependent on the amount of three selected independent variables. Optimized tablets remained floating for more than 24 h with a floating lag time of less than 4 min. Based on best fitting method, optimized formulation was found to follow Korsmeyer-Peppas release kinetic. Accelerated stability study revealed that optimized formulation was stable for three months without any major changes in assay, dissolution profile, floating lag time and other physical properties. School of Pharmacy, Shahid Beheshti University of Medical Sciences 2015-10-27 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45505/3/Published_article_in_press.pdf application/pdf en http://irep.iium.edu.my/45505/4/Proof_Articles_in_Press.pdf Senjoti, Faria Gias and Mahmood, Syed and Md. Jaffri, Juliana and Mandal, Uttam Kumar (2015) Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling. Iranian Journal of Pharmaceutical Research, 15 (1). pp. 1-34. ISSN 1726-6890 (In Press) http://ijpr.sbmu.ac.ir/article_1791_0.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Senjoti, Faria Gias Mahmood, Syed Md. Jaffri, Juliana Mandal, Uttam Kumar Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
description	An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken design of experiment where polymer content of HPMC and PEO at 1: 4 ratio (A), amount of sodium bi-carbonate (B), and amount of SSG (C) were adopted as independent variables. Floating lag time in sec (Y1), cumulative percent drug released at 1 h (Y2) and 12 h (Y3) were chosen as response variables. Tablets from the optimized formulation were also stored at accelerated stability condition (40°C and 75% RH) for 3 months to assess their stability profile. RSM could efficiently optimize the tablet composition with excellent prediction ability. In-vitro drug release until 12 h, floating lag time, and duration of floating were dependent on the amount of three selected independent variables. Optimized tablets remained floating for more than 24 h with a floating lag time of less than 4 min. Based on best fitting method, optimized formulation was found to follow Korsmeyer-Peppas release kinetic. Accelerated stability study revealed that optimized formulation was stable for three months without any major changes in assay, dissolution profile, floating lag time and other physical properties.
format	Article
author	Senjoti, Faria Gias Mahmood, Syed Md. Jaffri, Juliana Mandal, Uttam Kumar
author_facet	Senjoti, Faria Gias Mahmood, Syed Md. Jaffri, Juliana Mandal, Uttam Kumar
author_sort	Senjoti, Faria Gias
title	Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
title_short	Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
title_full	Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
title_fullStr	Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
title_full_unstemmed	Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling
title_sort	design and in-vitro evaluation of sustained release floating tablets of metformin hcl based on effervescence and swelling
publisher	School of Pharmacy, Shahid Beheshti University of Medical Sciences
publishDate	2015
url	http://irep.iium.edu.my/45505/ http://irep.iium.edu.my/45505/ http://irep.iium.edu.my/45505/3/Published_article_in_press.pdf http://irep.iium.edu.my/45505/4/Proof_Articles_in_Press.pdf
first_indexed	2023-09-18T21:04:45Z
last_indexed	2023-09-18T21:04:45Z
_version_	1777410858742185984

Design and in-vitro evaluation of sustained release floating tablets of metformin HCl based on effervescence and swelling

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