Metabolomics for bioactivity assessment of natural products
Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lea...
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| Language: | English |
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2015
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| Online Access: | http://irep.iium.edu.my/45724/ http://irep.iium.edu.my/45724/ http://irep.iium.edu.my/45724/1/abstract_book_and_certificate.pdf |
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iium-457242016-05-24T00:41:33Z http://irep.iium.edu.my/45724/ Metabolomics for bioactivity assessment of natural products Khatib, Alfi QD Chemistry Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal biofluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. 2015-10-21 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/45724/1/abstract_book_and_certificate.pdf Khatib, Alfi (2015) Metabolomics for bioactivity assessment of natural products. In: The 49th Pokjanas TOI International Seminar, 21-22 October 2015, Faculty of Pharmacy, Jakarta, Indonesia. http://pokjanastoi49.univpancasila.ac.id/index.php?isi=reviewer |
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Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QD Chemistry |
| spellingShingle |
QD Chemistry Khatib, Alfi Metabolomics for bioactivity assessment of natural products |
| description |
Nature is a huge library for bioactive compounds. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. Lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal biofluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. |
| format |
Conference or Workshop Item |
| author |
Khatib, Alfi |
| author_facet |
Khatib, Alfi |
| author_sort |
Khatib, Alfi |
| title |
Metabolomics for bioactivity assessment of natural products |
| title_short |
Metabolomics for bioactivity assessment of natural products |
| title_full |
Metabolomics for bioactivity assessment of natural products |
| title_fullStr |
Metabolomics for bioactivity assessment of natural products |
| title_full_unstemmed |
Metabolomics for bioactivity assessment of natural products |
| title_sort |
metabolomics for bioactivity assessment of natural products |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/45724/ http://irep.iium.edu.my/45724/ http://irep.iium.edu.my/45724/1/abstract_book_and_certificate.pdf |
| first_indexed |
2023-09-18T21:05:04Z |
| last_indexed |
2023-09-18T21:05:04Z |
| _version_ |
1777410878652547072 |