Formulation of PVA and PEG hydrogel via Freeze-Thaw method

The Hydrogels are three dimensional, water swollen structure composed of mainly hydrophilic homopolymers or copolymers like polyvinyl alcohol (PVA), Poly ethylene glycol (PEG) etc., utilized as a part of various biomedical fields, and are as yet producing for new encouraging applications. Physically...

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Main Authors:	Ahmed, Afnan Shihab, Bakhtiar, M. Taher, Mandal, Uttam Kumar, Md. Jaffri, Juliana
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/45847/ http://irep.iium.edu.my/45847/ http://irep.iium.edu.my/45847/1/45847.pdf

id	iium-45847
recordtype	eprints
spelling	iium-458472018-06-21T02:41:11Z http://irep.iium.edu.my/45847/ Formulation of PVA and PEG hydrogel via Freeze-Thaw method Ahmed, Afnan Shihab Bakhtiar, M. Taher Mandal, Uttam Kumar Md. Jaffri, Juliana RS Pharmacy and materia medica The Hydrogels are three dimensional, water swollen structure composed of mainly hydrophilic homopolymers or copolymers like polyvinyl alcohol (PVA), Poly ethylene glycol (PEG) etc., utilized as a part of various biomedical fields, and are as yet producing for new encouraging applications. Physically cross-linked synthetic polymers, PVA and PEG, hydrogels are excellent materials owing to their biological tissue like nature. Transparent PVA and PEG hydrogels with varying polymer concentrations were obtained by using freeze-thaw method.gel fraction and swelling behavior were investigated. PVA (Mw 195,000, Sigma-Aldrich), PEG 400 (Merck) hydrogels prepared by dissolving PVA in deionized water with concentrations (6%, 8%, and 10%), PEG with concentrations (1%, 3%, and 5%) were added and the gel were autoclaved at 121°C for 15min. The clear solution was poured into a Petri dish to undergo four consecutive cycles of 16 h freezing at -80°C and 8 h thawing at RT. Gel properties such as gel fraction, swelling index, water vapour transmission rate and mechanical strength were investigated. Four consecutive cycles of freezing and thawing formed an insoluble and entangled hydrogel. Present study demonstrates a systematic variation in physico-chemical properties of the developed using the freezing–thawing method with PVA and PEG as a function of polymer concentration. From the results with increasing PVA there is an increase in the gel fraction while increasing PEG concentration decreased gel fraction. However, increasing PVA decreased the swelling, and by adding PEG increases the swelling ratio and the water vapour transmission rate. The developed hydrogel using the freezing–thawing method with PVA and PEG was more swellable and flexible. 2015-11-12 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/45847/1/45847.pdf Ahmed, Afnan Shihab and Bakhtiar, M. Taher and Mandal, Uttam Kumar and Md. Jaffri, Juliana (2015) Formulation of PVA and PEG hydrogel via Freeze-Thaw method. In: 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (IPNaCs), 12th-13th Nov. 2015, Ramada Plaza, Malaka, Malaysia. (Unpublished) http://ipnacs.uitm.edu.my/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ahmed, Afnan Shihab Bakhtiar, M. Taher Mandal, Uttam Kumar Md. Jaffri, Juliana Formulation of PVA and PEG hydrogel via Freeze-Thaw method
description	The Hydrogels are three dimensional, water swollen structure composed of mainly hydrophilic homopolymers or copolymers like polyvinyl alcohol (PVA), Poly ethylene glycol (PEG) etc., utilized as a part of various biomedical fields, and are as yet producing for new encouraging applications. Physically cross-linked synthetic polymers, PVA and PEG, hydrogels are excellent materials owing to their biological tissue like nature. Transparent PVA and PEG hydrogels with varying polymer concentrations were obtained by using freeze-thaw method.gel fraction and swelling behavior were investigated. PVA (Mw 195,000, Sigma-Aldrich), PEG 400 (Merck) hydrogels prepared by dissolving PVA in deionized water with concentrations (6%, 8%, and 10%), PEG with concentrations (1%, 3%, and 5%) were added and the gel were autoclaved at 121°C for 15min. The clear solution was poured into a Petri dish to undergo four consecutive cycles of 16 h freezing at -80°C and 8 h thawing at RT. Gel properties such as gel fraction, swelling index, water vapour transmission rate and mechanical strength were investigated. Four consecutive cycles of freezing and thawing formed an insoluble and entangled hydrogel. Present study demonstrates a systematic variation in physico-chemical properties of the developed using the freezing–thawing method with PVA and PEG as a function of polymer concentration. From the results with increasing PVA there is an increase in the gel fraction while increasing PEG concentration decreased gel fraction. However, increasing PVA decreased the swelling, and by adding PEG increases the swelling ratio and the water vapour transmission rate. The developed hydrogel using the freezing–thawing method with PVA and PEG was more swellable and flexible.
format	Conference or Workshop Item
author	Ahmed, Afnan Shihab Bakhtiar, M. Taher Mandal, Uttam Kumar Md. Jaffri, Juliana
author_facet	Ahmed, Afnan Shihab Bakhtiar, M. Taher Mandal, Uttam Kumar Md. Jaffri, Juliana
author_sort	Ahmed, Afnan Shihab
title	Formulation of PVA and PEG hydrogel via Freeze-Thaw method
title_short	Formulation of PVA and PEG hydrogel via Freeze-Thaw method
title_full	Formulation of PVA and PEG hydrogel via Freeze-Thaw method
title_fullStr	Formulation of PVA and PEG hydrogel via Freeze-Thaw method
title_full_unstemmed	Formulation of PVA and PEG hydrogel via Freeze-Thaw method
title_sort	formulation of pva and peg hydrogel via freeze-thaw method
publishDate	2015
url	http://irep.iium.edu.my/45847/ http://irep.iium.edu.my/45847/ http://irep.iium.edu.my/45847/1/45847.pdf
first_indexed	2023-09-18T21:05:15Z
last_indexed	2023-09-18T21:05:15Z
_version_	1777410890076782592

Formulation of PVA and PEG hydrogel via Freeze-Thaw method

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