Nanosuspension technology in salicylic acid and its particle size characterization

Salicylic acid (SA) is known to have keratolytic activity for the treatment of skin related disease such as acne and psoriasis. However, it usually causes side effects such as skin irritation. Also, SA is poorly soluble in water making it difficult to formulate. This study aims to explore the use o...

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Main Authors:	Ab. Hadi, Hazrina, Awadh, Ammar Ihsan Jawad
Format:	Conference or Workshop Item
Language:	English English
Published:	2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/45897/ http://irep.iium.edu.my/45897/ http://irep.iium.edu.my/45897/4/MPS_progr_book.pdf http://irep.iium.edu.my/45897/5/MPS_SA.pdf

id	iium-45897
recordtype	eprints
spelling	iium-458972016-07-17T20:29:35Z http://irep.iium.edu.my/45897/ Nanosuspension technology in salicylic acid and its particle size characterization Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad RS Pharmacy and materia medica Salicylic acid (SA) is known to have keratolytic activity for the treatment of skin related disease such as acne and psoriasis. However, it usually causes side effects such as skin irritation. Also, SA is poorly soluble in water making it difficult to formulate. This study aims to explore the use of nanosuspension technology in enhancing the solubility of SA in aqueous solutions and provide a control release to reduce the side effects of salicylic acid by reducing its particle size into nanometer scale. This research project focused on the use of oil-in-water emulsification followed by solvent evaporation technique. The use of different amounts of ethyl acetate will be evaluated. This technique was chosen as it has high drug solubilization and capable of producing large scale because of simple manufacturing method and using low-cost materials. The manipulation of different amount of organic solvent, ethyl acetate has an impact in the particle size. Result shows that increase amount of ethyl acetate give smaller average particle size. However, the particle size increases after the process of centrifugation and freeze-drying. The percentage yields of the final products were shown to be low (below 25%). The study has shown that it is possible to reduce the particle size of SA to a nano-sized diameter. Thus the solubility of salicylic acid can be enhanced. However, more extensive research should be done to provide a more concrete conclusion. An improved understanding of the formulation factors will further advance the value of nanosuspension in topical drug delivery. 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/45897/4/MPS_progr_book.pdf application/pdf en http://irep.iium.edu.my/45897/5/MPS_SA.pdf Ab. Hadi, Hazrina and Awadh, Ammar Ihsan Jawad (2015) Nanosuspension technology in salicylic acid and its particle size characterization. In: 12th MPS Malaysia Pharmacy Scientific Conference 2015, 13th-15th Nov 2015, Taylor's University, Lakeside Campus, Selangor, Malaysia. (Unpublished) http://www.mps.org.my/mpspsc2015/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad Nanosuspension technology in salicylic acid and its particle size characterization
description	Salicylic acid (SA) is known to have keratolytic activity for the treatment of skin related disease such as acne and psoriasis. However, it usually causes side effects such as skin irritation. Also, SA is poorly soluble in water making it difficult to formulate. This study aims to explore the use of nanosuspension technology in enhancing the solubility of SA in aqueous solutions and provide a control release to reduce the side effects of salicylic acid by reducing its particle size into nanometer scale. This research project focused on the use of oil-in-water emulsification followed by solvent evaporation technique. The use of different amounts of ethyl acetate will be evaluated. This technique was chosen as it has high drug solubilization and capable of producing large scale because of simple manufacturing method and using low-cost materials. The manipulation of different amount of organic solvent, ethyl acetate has an impact in the particle size. Result shows that increase amount of ethyl acetate give smaller average particle size. However, the particle size increases after the process of centrifugation and freeze-drying. The percentage yields of the final products were shown to be low (below 25%). The study has shown that it is possible to reduce the particle size of SA to a nano-sized diameter. Thus the solubility of salicylic acid can be enhanced. However, more extensive research should be done to provide a more concrete conclusion. An improved understanding of the formulation factors will further advance the value of nanosuspension in topical drug delivery.
format	Conference or Workshop Item
author	Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad
author_facet	Ab. Hadi, Hazrina Awadh, Ammar Ihsan Jawad
author_sort	Ab. Hadi, Hazrina
title	Nanosuspension technology in salicylic acid and its particle size characterization
title_short	Nanosuspension technology in salicylic acid and its particle size characterization
title_full	Nanosuspension technology in salicylic acid and its particle size characterization
title_fullStr	Nanosuspension technology in salicylic acid and its particle size characterization
title_full_unstemmed	Nanosuspension technology in salicylic acid and its particle size characterization
title_sort	nanosuspension technology in salicylic acid and its particle size characterization
publishDate	2015
url	http://irep.iium.edu.my/45897/ http://irep.iium.edu.my/45897/ http://irep.iium.edu.my/45897/4/MPS_progr_book.pdf http://irep.iium.edu.my/45897/5/MPS_SA.pdf
first_indexed	2023-09-18T21:05:19Z
last_indexed	2023-09-18T21:05:19Z
_version_	1777410894478704640

Nanosuspension technology in salicylic acid and its particle size characterization

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