Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design

Context: High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer–plasticizer carrier significantly affects drug solubility and tableting property of SD. Objective: To evaluate and optimize the combined effect of a bina...

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Main Authors:	Kyaw Oo, May, Mandal, Uttam Kumar, Chatterjee, Bappaditya
Format:	Article
Language:	English English
Published:	Taylor and Francis 2015
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/46058/ http://irep.iium.edu.my/46058/ http://irep.iium.edu.my/46058/1/published_copy.pdf http://irep.iium.edu.my/46058/4/Polymeric%20behavior%20evaluation%20of%20PVP%20K30-%20poloxamer%20binary%20carrier%20for%20solid%20dispersed%20nisoldipine%20by%20experimental%20design.pdf

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spelling	iium-460582018-01-19T03:03:29Z http://irep.iium.edu.my/46058/ Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design Kyaw Oo, May Mandal, Uttam Kumar Chatterjee, Bappaditya RS Pharmacy and materia medica Context: High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer–plasticizer carrier significantly affects drug solubility and tableting property of SD. Objective: To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on nisoldipine solubility and tensile strength of amorphous SD compact (SDcompact) by experimental design. Materials and methods: SD of nisoldpine (SDnisol) was prepared by melt mixing with different PVP K30 and poloxamer amount. A 32 factorial design was employed using nisoldipine solubility and tensile strength of SDcompact as response variables. Statistical optimization by design expert software, and SDnisol characterization using ATR FTIR, DSC and microscopy were done. Results: PVP K30:poloxamer, at a ratio of 3.73:6.63, was selected as the optimized combination of binary polymeric carrier resulting nisoldipine solubility of 115 mg/mL and tensile strength of 1.19 N/m2 . Discussion: PVP K30 had significant positive effect on both responses. Increase in poloxamer concentration after a certain level decreased nisoldipine solubility and tensile strength of SDcompact. Conclusion: An optimized PVP K30–poloxamer binary composition for SD carrier was developed. Tensile strength of SDcompact can be considered as a response for experimental design to optimize SD. Taylor and Francis 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46058/1/published_copy.pdf application/pdf en http://irep.iium.edu.my/46058/4/Polymeric%20behavior%20evaluation%20of%20PVP%20K30-%20poloxamer%20binary%20carrier%20for%20solid%20dispersed%20nisoldipine%20by%20experimental%20design.pdf Kyaw Oo, May and Mandal, Uttam Kumar and Chatterjee, Bappaditya (2015) Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design. Pharmaceutical Development Technology. pp. 1-11. ISSN 1083-7450 (P) 1097-9867 (O) (In Press) http://www.tandfonline.com/loi/iphd20#.VmeMT_l97IU
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Kyaw Oo, May Mandal, Uttam Kumar Chatterjee, Bappaditya Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
description	Context: High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer–plasticizer carrier significantly affects drug solubility and tableting property of SD. Objective: To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on nisoldipine solubility and tensile strength of amorphous SD compact (SDcompact) by experimental design. Materials and methods: SD of nisoldpine (SDnisol) was prepared by melt mixing with different PVP K30 and poloxamer amount. A 32 factorial design was employed using nisoldipine solubility and tensile strength of SDcompact as response variables. Statistical optimization by design expert software, and SDnisol characterization using ATR FTIR, DSC and microscopy were done. Results: PVP K30:poloxamer, at a ratio of 3.73:6.63, was selected as the optimized combination of binary polymeric carrier resulting nisoldipine solubility of 115 mg/mL and tensile strength of 1.19 N/m2 . Discussion: PVP K30 had significant positive effect on both responses. Increase in poloxamer concentration after a certain level decreased nisoldipine solubility and tensile strength of SDcompact. Conclusion: An optimized PVP K30–poloxamer binary composition for SD carrier was developed. Tensile strength of SDcompact can be considered as a response for experimental design to optimize SD.
format	Article
author	Kyaw Oo, May Mandal, Uttam Kumar Chatterjee, Bappaditya
author_facet	Kyaw Oo, May Mandal, Uttam Kumar Chatterjee, Bappaditya
author_sort	Kyaw Oo, May
title	Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
title_short	Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
title_full	Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
title_fullStr	Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
title_full_unstemmed	Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
title_sort	polymeric behavior evaluation of pvp k30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design
publisher	Taylor and Francis
publishDate	2015
url	http://irep.iium.edu.my/46058/ http://irep.iium.edu.my/46058/ http://irep.iium.edu.my/46058/1/published_copy.pdf http://irep.iium.edu.my/46058/4/Polymeric%20behavior%20evaluation%20of%20PVP%20K30-%20poloxamer%20binary%20carrier%20for%20solid%20dispersed%20nisoldipine%20by%20experimental%20design.pdf
first_indexed	2023-09-18T21:05:33Z
last_indexed	2023-09-18T21:05:33Z
_version_	1777410908482437120

Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design

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