Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model

Hyperlipidaemia remains the most important risk factor for cardiovascular events mainly the atherosclerosis, a progressive process occurs within the walls of large and medium arteries. Eurycoma Longifolia (EL), Simaroubaceae is a herb that has been used since ancient times to combat many health prob...

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Main Authors:	A. J., Fakhria, Saxena, Anil Kumar, Al-Ani, Imad Matloub Dally, A.Talib, Norlelawati, Hanim, M. R., Ku Zaifah, Norsidah
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/46110/ http://irep.iium.edu.my/46110/1/46110.pdf

id	iium-46110
recordtype	eprints
spelling	iium-461102016-02-29T01:47:59Z http://irep.iium.edu.my/46110/ Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model A. J., Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Hanim, M. R. Ku Zaifah, Norsidah Q Science (General) Hyperlipidaemia remains the most important risk factor for cardiovascular events mainly the atherosclerosis, a progressive process occurs within the walls of large and medium arteries. Eurycoma Longifolia (EL), Simaroubaceae is a herb that has been used since ancient times to combat many health problems and for other medicinal purposes. Its effects are generally attributed to its bioactive constituents. To examine the effects of EL on lipid profile and intima media thickness (IMT) in aorta of Sprague Dawley (SD) rats by high- fat induction. Healthy male SD rats were divided into 4 groups of 6 animals and treated for 12 weeks as follow: Group I was given only normal diet, Group II was given normal diet and EL, Group III was given only high fat diet (HFD), Group IV was given HFD and EL extracts. The thickness of intima media of aortas were photographed and measured with Dino-Captured® 2.0. Statistical significance was determined by one way (ANOVA). P values less than 0.05 were considered significant. In this study, the aortic IMT was significantly increased in the HFD group than that of ND (p< 0.05), on the other hand the aortic IMT was significantly reduced in HFDEL group than that of HFD group (p<0.05). Results represent mean (SD) of 5 rats per group. Results of this study showed that the aqueous extract of EL attenuated the formation of atherosclerotic plaques in aorta of rats by HFD induction. 2015 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/46110/1/46110.pdf A. J., Fakhria and Saxena, Anil Kumar and Al-Ani, Imad Matloub Dally and A.Talib, Norlelawati and Hanim, M. R. and Ku Zaifah, Norsidah (2015) Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model. In: 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (IPNaCs), 12th-13th Nov. 2015, Ramada Plaza, Malaka, Malaysia. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) A. J., Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Hanim, M. R. Ku Zaifah, Norsidah Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
description	Hyperlipidaemia remains the most important risk factor for cardiovascular events mainly the atherosclerosis, a progressive process occurs within the walls of large and medium arteries. Eurycoma Longifolia (EL), Simaroubaceae is a herb that has been used since ancient times to combat many health problems and for other medicinal purposes. Its effects are generally attributed to its bioactive constituents. To examine the effects of EL on lipid profile and intima media thickness (IMT) in aorta of Sprague Dawley (SD) rats by high- fat induction. Healthy male SD rats were divided into 4 groups of 6 animals and treated for 12 weeks as follow: Group I was given only normal diet, Group II was given normal diet and EL, Group III was given only high fat diet (HFD), Group IV was given HFD and EL extracts. The thickness of intima media of aortas were photographed and measured with Dino-Captured® 2.0. Statistical significance was determined by one way (ANOVA). P values less than 0.05 were considered significant. In this study, the aortic IMT was significantly increased in the HFD group than that of ND (p< 0.05), on the other hand the aortic IMT was significantly reduced in HFDEL group than that of HFD group (p<0.05). Results represent mean (SD) of 5 rats per group. Results of this study showed that the aqueous extract of EL attenuated the formation of atherosclerotic plaques in aorta of rats by HFD induction.
format	Conference or Workshop Item
author	A. J., Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Hanim, M. R. Ku Zaifah, Norsidah
author_facet	A. J., Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Hanim, M. R. Ku Zaifah, Norsidah
author_sort	A. J., Fakhria
title	Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
title_short	Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
title_full	Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
title_fullStr	Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
title_full_unstemmed	Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
title_sort	eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model
publishDate	2015
url	http://irep.iium.edu.my/46110/ http://irep.iium.edu.my/46110/1/46110.pdf
first_indexed	2023-09-18T21:05:38Z
last_indexed	2023-09-18T21:05:38Z
_version_	1777410914480291840

Eurycoma longifolia extract exhibits anti-atherosclerotic effects in an in-vivo model

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