Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats

Diabetes mellitus type-2 prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate the differences of metobolites profile in the serum of rats in dif...

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Main Authors:	Khatib, Alfi, Perumal, Vikneswari, Abdul Hamid, Azizah, Saari, Khozirah, Nik Jusoh, Nik Idris
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/46152/ http://irep.iium.edu.my/46152/1/APTFI.pdf

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recordtype	eprints
spelling	iium-461522016-05-20T07:56:35Z http://irep.iium.edu.my/46152/ Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Saari, Khozirah Nik Jusoh, Nik Idris Q Science (General) Diabetes mellitus type-2 prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate the differences of metobolites profile in the serum of rats in different conditions (healthy, diabetes, Cosmos caudatus and metformin treated) using NMR based-metabolomics approach. The ethanol 80 % extract of C. caudatus was force fed to diabetic rats. Streptozotocin was used to induce the obese rat to become diabetic (ob-db). Rats were divided into four groups: healthy rat, ob-db treated with 300 mg/kg metformin and ob-db treated with 200 mg/kg of C. caudatus. The NMR serum spectra of rats were statistically correlated using multivariate data analysis to discriminate the groups and to identify the metabolites responsible for discrimination. Glucose level which was elevated in type 2 diabetic rats can be reduced to the normal range. Interestingly metformin caused elevation of ethanol, lactate and alanine which were not observed in C. caudatus treated rats. Other significant metabolites which have been identified were glucose, ethanol, alanine and lactate. This study suggested that C. caudatus is potential for the treatment of type 2 diabetes. 2015-11-23 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/46152/1/APTFI.pdf Khatib, Alfi and Perumal, Vikneswari and Abdul Hamid, Azizah and Saari, Khozirah and Nik Jusoh, Nik Idris (2015) Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats. In: 8th Asian Network of Research on Antidiabetic Plants (ANRAP), International Seminar 2015, 23rd-25th Nov. 2015, Grand Bluewave Hotel, Shah Alam, Selangor.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Saari, Khozirah Nik Jusoh, Nik Idris Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
description	Diabetes mellitus type-2 prevalence is increasing rapidly worldwide. It is resulted from the combination of impaired insulin secretion with reduced insulin sensitivity of the target tissues. The objective of this study is to evaluate the differences of metobolites profile in the serum of rats in different conditions (healthy, diabetes, Cosmos caudatus and metformin treated) using NMR based-metabolomics approach. The ethanol 80 % extract of C. caudatus was force fed to diabetic rats. Streptozotocin was used to induce the obese rat to become diabetic (ob-db). Rats were divided into four groups: healthy rat, ob-db treated with 300 mg/kg metformin and ob-db treated with 200 mg/kg of C. caudatus. The NMR serum spectra of rats were statistically correlated using multivariate data analysis to discriminate the groups and to identify the metabolites responsible for discrimination. Glucose level which was elevated in type 2 diabetic rats can be reduced to the normal range. Interestingly metformin caused elevation of ethanol, lactate and alanine which were not observed in C. caudatus treated rats. Other significant metabolites which have been identified were glucose, ethanol, alanine and lactate. This study suggested that C. caudatus is potential for the treatment of type 2 diabetes.
format	Conference or Workshop Item
author	Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Saari, Khozirah Nik Jusoh, Nik Idris
author_facet	Khatib, Alfi Perumal, Vikneswari Abdul Hamid, Azizah Saari, Khozirah Nik Jusoh, Nik Idris
author_sort	Khatib, Alfi
title	Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
title_short	Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
title_full	Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
title_fullStr	Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
title_full_unstemmed	Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats
title_sort	evaluation of anti-diabetic properties of cosmos caudatus leaves in obese-diabetic induced rats
publishDate	2015
url	http://irep.iium.edu.my/46152/ http://irep.iium.edu.my/46152/1/APTFI.pdf
first_indexed	2023-09-18T21:05:43Z
last_indexed	2023-09-18T21:05:43Z
_version_	1777410919045791744

Evaluation of anti-diabetic properties of cosmos Caudatus leaves in obese-diabetic induced rats

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