Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations

Abstract: Damage to the meniscus and the anterior cruciate ligament alters the pattern of loading in the knee joint and frequently leads to cartilage degeneration and osteoarthritis. This study aimed to evaluate the area of greatest impact after traumatic osteoarthritic induction at the knee joint i...

Full description

Bibliographic Details
Main Authors:	Alfaqeh, Hamoud Hussein Mohammed, Samsudin OC, Samsudin Othman Casim, MY, Norhamdan, HC, Chen, SSH, Sharifah, BS, Aminuddin, BHI, Ruszymah
Format:	Article
Language:	English
Published:	Tissue Engineering and Regenerative Medicine Society of Malaysia 2014
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/1/Medial_menisectomy_of_ACL_2014.pdf

id	iium-46163
recordtype	eprints
spelling	iium-461632018-06-12T07:45:56Z http://irep.iium.edu.my/46163/ Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations Alfaqeh, Hamoud Hussein Mohammed Samsudin OC, Samsudin Othman Casim MY, Norhamdan HC, Chen SSH, Sharifah BS, Aminuddin BHI, Ruszymah RD701 Orthopedics Abstract: Damage to the meniscus and the anterior cruciate ligament alters the pattern of loading in the knee joint and frequently leads to cartilage degeneration and osteoarthritis. This study aimed to evaluate the area of greatest impact after traumatic osteoarthritic induction at the knee joint in sheep model. Osteoarthritis was induced unilaterally at the right hind knee of six sheep by surgical resection of the anterior cruciate ligament and medial meniscus. After 3 weeks recovery period, sheep were exercised once daily by running a 100 meters distance on a hard surface for 3 weeks. Gross and histological assessments were done. Six regions examined were; the patella, patella femoral groove, medial femoral condyle, lateral femoral condyle, medial tibia plateau and lateral tibia plateau. Their mean International Cartilage Repair Society grading was: 2.5±0.42, 3.3±0.17, 2.25±0.38, 1.33±0.25, 2±0.37 and 1.5±0.22 respectively. The control from all samples scored zero at the above regions. The lesions at various regions were significantly higher compared to the control (p < 0.05). Patella femoral groove was significantly higher compare to all other regions except for Patella. Lateral femoral condyle was the least (p < 0.05). Histological staining revealed defined osteoarthritic changes. Total excision of medial meniscus and anterior cruciate ligament followed by exercise regime induced osteoarthritis in the affected knee joint. The changes in pattern of degeneration, affected patella femoral groove the most; followed by the patella and medial femoral condyle, then medial tibia plateau, lateral tibia plateau and lastly the lateral femoral condyle. Tissue Engineering and Regenerative Medicine Society of Malaysia 2014-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46163/1/Medial_menisectomy_of_ACL_2014.pdf Alfaqeh, Hamoud Hussein Mohammed and Samsudin OC, Samsudin Othman Casim and MY, Norhamdan and HC, Chen and SSH, Sharifah and BS, Aminuddin and BHI, Ruszymah (2014) Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations. Regenerative Research, 3 (1). pp. 8-16. ISSN 2232-0822 (Online) http://regres.tesma.org.my/ E-ISSN 2232-0822
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Alfaqeh, Hamoud Hussein Mohammed Samsudin OC, Samsudin Othman Casim MY, Norhamdan HC, Chen SSH, Sharifah BS, Aminuddin BHI, Ruszymah Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
description	Abstract: Damage to the meniscus and the anterior cruciate ligament alters the pattern of loading in the knee joint and frequently leads to cartilage degeneration and osteoarthritis. This study aimed to evaluate the area of greatest impact after traumatic osteoarthritic induction at the knee joint in sheep model. Osteoarthritis was induced unilaterally at the right hind knee of six sheep by surgical resection of the anterior cruciate ligament and medial meniscus. After 3 weeks recovery period, sheep were exercised once daily by running a 100 meters distance on a hard surface for 3 weeks. Gross and histological assessments were done. Six regions examined were; the patella, patella femoral groove, medial femoral condyle, lateral femoral condyle, medial tibia plateau and lateral tibia plateau. Their mean International Cartilage Repair Society grading was: 2.5±0.42, 3.3±0.17, 2.25±0.38, 1.33±0.25, 2±0.37 and 1.5±0.22 respectively. The control from all samples scored zero at the above regions. The lesions at various regions were significantly higher compared to the control (p < 0.05). Patella femoral groove was significantly higher compare to all other regions except for Patella. Lateral femoral condyle was the least (p < 0.05). Histological staining revealed defined osteoarthritic changes. Total excision of medial meniscus and anterior cruciate ligament followed by exercise regime induced osteoarthritis in the affected knee joint. The changes in pattern of degeneration, affected patella femoral groove the most; followed by the patella and medial femoral condyle, then medial tibia plateau, lateral tibia plateau and lastly the lateral femoral condyle.
format	Article
author	Alfaqeh, Hamoud Hussein Mohammed Samsudin OC, Samsudin Othman Casim MY, Norhamdan HC, Chen SSH, Sharifah BS, Aminuddin BHI, Ruszymah
author_facet	Alfaqeh, Hamoud Hussein Mohammed Samsudin OC, Samsudin Othman Casim MY, Norhamdan HC, Chen SSH, Sharifah BS, Aminuddin BHI, Ruszymah
author_sort	Alfaqeh, Hamoud Hussein Mohammed
title	Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
title_short	Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
title_full	Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
title_fullStr	Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
title_full_unstemmed	Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
title_sort	anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations
publisher	Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate	2014
url	http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/ http://irep.iium.edu.my/46163/1/Medial_menisectomy_of_ACL_2014.pdf
first_indexed	2023-09-18T21:05:43Z
last_indexed	2023-09-18T21:05:43Z
_version_	1777410919788183552

Anterior cruciate ligament resection and medial meniscectomy result in multifocal cartilage degenerations

Similar Items