Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach

Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach

In this study, we compared the efficacy of the overall meta-analysis estimates that used only the available aggregate data (AD) studies against those that combined the available AD and individual patient data (IPD) studies. We introduced some modifications to the existing two-stage method for comb...

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Bibliographic Details
Main Authors: Nik Idris, Nik Ruzni, Misran, Nurul Afiqah
Format: Article
Language:English
Published: Canadian Center of Science and Education 2015
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/1/PublishedArticle.pdf
id iium-46243
recordtype eprints
spelling iium-462432016-12-19T09:27:52Z http://irep.iium.edu.my/46243/ Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach Nik Idris, Nik Ruzni Misran, Nurul Afiqah Q Science (General) In this study, we compared the efficacy of the overall meta-analysis estimates that used only the available aggregate data (AD) studies against those that combined the available AD and individual patient data (IPD) studies. We introduced some modifications to the existing two-stage method for combining the AD and IPD studies. We evaluated the effects of these modifications on the estimates of the overall treatment effect, and investigated the influence of the number of studies included in the meta-analysis, N, and the ratio of AD: IPD on these estimates. We used percentage relative bias (PRB), root mean-square-error (RMSE), and coverage probability to assess the overall efficiency of these estimates. The results revealed the superiority of estimates from the combined AD: IPD studies over those that utilized only the available AD in terms of both the accuracy and the RMSE. We found that the current method for combining the AD:IPD studies provided poor coverage probabilityand that the proposed methods generated improved coverage probability by more than 40% while maintaining the level of bias and RMSE at par to their existing counterparts. These findings validated the importance of utilizing both the AD and IPD studies whenever they are available, and demonstrated the significance of proper technique for combining these studies in order to obtain better overall estimates. Canadian Center of Science and Education 2015-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46243/1/PublishedArticle.pdf Nik Idris, Nik Ruzni and Misran, Nurul Afiqah (2015) Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach. Modern Applied Science, 9 (13). pp. 237-246. ISSN 1913-1844 (P), 1913-1852 (O) http://ccsenet.org/journal/index.php/mas/index 10.5539/mas.v9n13p237
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic Q Science (General)
spellingShingle Q Science (General)
Nik Idris, Nik Ruzni
Misran, Nurul Afiqah
Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
description In this study, we compared the efficacy of the overall meta-analysis estimates that used only the available aggregate data (AD) studies against those that combined the available AD and individual patient data (IPD) studies. We introduced some modifications to the existing two-stage method for combining the AD and IPD studies. We evaluated the effects of these modifications on the estimates of the overall treatment effect, and investigated the influence of the number of studies included in the meta-analysis, N, and the ratio of AD: IPD on these estimates. We used percentage relative bias (PRB), root mean-square-error (RMSE), and coverage probability to assess the overall efficiency of these estimates. The results revealed the superiority of estimates from the combined AD: IPD studies over those that utilized only the available AD in terms of both the accuracy and the RMSE. We found that the current method for combining the AD:IPD studies provided poor coverage probabilityand that the proposed methods generated improved coverage probability by more than 40% while maintaining the level of bias and RMSE at par to their existing counterparts. These findings validated the importance of utilizing both the AD and IPD studies whenever they are available, and demonstrated the significance of proper technique for combining these studies in order to obtain better overall estimates.
format Article
author Nik Idris, Nik Ruzni
Misran, Nurul Afiqah
author_facet Nik Idris, Nik Ruzni
Misran, Nurul Afiqah
author_sort Nik Idris, Nik Ruzni
title Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
title_short Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
title_full Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
title_fullStr Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
title_full_unstemmed Integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
title_sort integrating aggregate-data and individual-patient-data in meta-analysis: an empirical assessment and an alternative methodfor the two-stage approach
publisher Canadian Center of Science and Education
publishDate 2015
url http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/
http://irep.iium.edu.my/46243/1/PublishedArticle.pdf
first_indexed 2023-09-18T21:05:49Z
last_indexed 2023-09-18T21:05:49Z
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