What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

The objectives of this study were to determine the effects of obesity on unbound trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic (PD) targets of piperacillin and meropenem in critically ill patients. This study retrospectively analysed therapeutic-drug-monitorin...

Full description

Bibliographic Details
Main Authors:	Alobaid, Abdulaziz S., Brinkmann, Alexander, Frey, Otto R., Roehr, Anka C., Luque, Sonia, Grau, Santiago, Wong , Gloria, Abdul Aziz, Mohd. Hafiz, Roberts, Michael S., Lipman, Jeffrey, Roberts, Jason A.
Format:	Article
Language:	English
Published:	Oxford Journals 2015
Subjects:	QR Microbiology RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/46717/ http://irep.iium.edu.my/46717/ http://irep.iium.edu.my/46717/ http://irep.iium.edu.my/46717/1/J._Antimicrob._Chemother.-2015-Alobaid-jac-dkv412.pdf

Similar Items

Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2014)

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2015)

Pharmacokinetics of meropenem in critically ill patients receiving continuous venovenous haemofiltration: A randomized controlled trial of continuous infusion versus intermittent bolus administration
by: Jamal, Janattul-Ain, et al.
Published: (2015)

Prolonged infusion piperacillin-tazobactam decreases mortality and improves outcomes in severely ill patients: results of a systematic review and meta-analysis
by: Rhodes, Nathaniel J., et al.
Published: (2018)

Daily Clinical Dose (D) poorly predicts trough serum methadone concentration (C trough) in patients undergo methadone maintenance therapy with good adherence
by: Mohamed Nazar, Nor Ilyani, et al.
Published: (2014)

Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients
by: Cheng, Vesa, et al.
Published: (2019)

Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2017)

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
by: Roberts, Jason A., et al.
Published: (2014)

Nutritional management of the critically ill obese patient
by: Mat Nor, Mohd Basri, et al.
Published: (2018)

Impact of the MIC of piperacillin/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the Bacteraemia-MIC project.
by: Delgado-Valverde, Mercedes, et al.
Published: (2016)

Potential lipase inhibitor for obesity treatment
by: Alias, Norsyuhada, et al.
Published: (2015)

The Third National Health and Morbidity Survey: Prevalence of obesity, and abdominal obesity among the Malaysian elderly population
by: Shahar, Suzana, et al.
Published: (2012)

Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2015)

Continuous beta-lactam infusion in critically ill patients: the clinical evidence
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2012)

Anti-obesity potential of selected tropical plants via pancreatic lipase inhibition
by: Alias, Norsyuhada, et al.
Published: (2017)

The DALI study: defining antibiotic levels in intensive care unit patients: prolonged infusion of beta-lactam antibiotics in critically ill patients
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2013)

Antibiotic dosing for multidrug-resistant pathogen pneumonia
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2017)

Defining antibiotic dosing in lung infections
by: Jamal, Jannatul-Ain, et al.
Published: (2013)

Population pharmacokinetics of doripenem in critically ill patients with sepsis in a Malaysian intensive care unit
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2016)

Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2014)

Modulation of gut microbiome by probiotics in obesity and related metabolic abnormalities / Mohd Shafiq Aazmi
by: Aazmi, Mohd Shafiq
Published: (2017)

The BLISS study: Beta-Lactam infusion in severe sepsis-randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis in a Malaysian ICU setting
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2015)

Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System
by: Nurul Akmal, Che Lah, et al.
Published: (2016)

Prolonged administration of β-lactam antibiotics - a comprehensive review and critical appraisal
by: Osthoff, Michael, et al.
Published: (2016)

Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia
by: Sulaiman, Helmi, et al.
Published: (2017)

Antibiotic dosing during extracorporeal membrane oxygenation
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2018)

Effectiveness and prescription pattern of lipid-lowering therapy and its associated factors among patients with type 2 diabetes mellitus in Malaysian primary care settings
by: Elnaem, Mohamed Hassan, et al.
Published: (2019)

Assessment of lipid-lowering therapy prescribing among patients with type 2 Diabetes Mellitus in Malaysian primary care settings
by: Elnaem, Mohamed Hassan, et al.
Published: (2017)

Statin therapy prescribing for patients with type 2 diabetes mellitus: a review of current evidence and challenges
by: Elnaem, Mohamed Hassan, et al.
Published: (2017)

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
by: Ferro, Riccardo, et al.
Published: (2018)

Ant 4,4, a polyamine-anthracene conjugate, induces cell death and recovery in human promyelogenous leukemia cells (HL-60)
by: Rui, Traquete, et al.
Published: (2013)

The polyamine transport system: A means of selective delivery of potentially toxic agents to cancer cells?
by: Abdul Ghani, Radiah, et al.
Published: (2009)

Halal lifestyle and cancer
by: Amid, Azura
Published: (2011)

In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
by: Harun, Aiza, et al.
Published: (2011)

Mitochondrial DNA quantity changes in leucocytes of cancer patients on cisplatin and 5-fluorouracil regimen
by: Khaing, Ei Phyo, et al.
Published: (2016)

Arborinine from Glycosmis Pentaphylla (retz.) DC induces apoptosis through activation of Caspase-3/7 in human mammary gland Adenocarcinoma (MCF-7) cell line
by: Mohd Hussain, Nurlaili Najmie, et al.
Published: (2016)

Studies on the red sea sponge Haliclona sp. for its chemical and cytotoxic properties
by: Al-Massarani, Shaza Mohamed, et al.
Published: (2016)

Prophylactic effects of Nigella sativa extract and thymoquinone against cyclophosphamide-induced sperm head abnormalities and chromatin instability in mice
by: Abdul Rahman, Suzanah, et al.
Published: (2017)

Patterns of initial opioid prescribing and its association with short and long-term use among opioid naïve patients: Experience from Malaysia
by: Zin, Che Suraya, et al.
Published: (2018)

Investigation of plasma concentrations of IL-6 and IL-10 in short and long-term opioid users with non-cancer pain
by: Zin, Che Suraya, et al.
Published: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gh1putpeq3e1sqiitveh1kjm7g