Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium
Sphathiphyllum cannifolium is abundantly planted in Malaysia as a landscape plant. However, this plant also has medical benefit to human as it was previously found to possess anti-bacteria and anti-cancer activities. In the present study, the plant was evaluated for its anti inflammatory activity an...
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Universiti Teknologi Malaysia
2015
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iium-474302016-06-06T08:21:01Z http://irep.iium.edu.my/47430/ Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium Ahmad Raus, Raha Abdullah, Norhayati Ismail, Nurul Fakhriah Shahbuddin, Munira QK Botany SB Plant culture TP248.13 Biotechnology Sphathiphyllum cannifolium is abundantly planted in Malaysia as a landscape plant. However, this plant also has medical benefit to human as it was previously found to possess anti-bacteria and anti-cancer activities. In the present study, the plant was evaluated for its anti inflammatory activity and the optimum condition for the extraction of bioactive compounds with anti inflammatory activity was determined. Semi purification of the compounds possessing anti inflammatory activity was conducted as well. To extract the bioactive compound, sonication with methanol as a solvent extraction was carried out. Face-Centered Central Composite Design (FCCCD) and Response Surface Methodology (RSM) were used to design and identify the optimum condition to extract the compound, respectively. The results showed that the plant was positive for the anti inflammatory activity with IC50 6.3 µg/ml. Sonication for 60 min at 40°C using medium frequency was the optimum condition to carry out the extraction for bioactive compounds. After semi purification of the initial crude extract by solvent partitioning, chloroform fraction was found to be positive for anti inflammatory activity. In conclusion, this study suggested that S. cannifolium possess anti inflammatory activity and should be further analyzed to identify the specific compounds that responsible for this activity. Universiti Teknologi Malaysia 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47430/1/6713-18450-1-SM.pdf Ahmad Raus, Raha and Abdullah, Norhayati and Ismail, Nurul Fakhriah and Shahbuddin, Munira (2015) Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium. Jurnal Teknologi, 77 (24). pp. 89-93. ISSN 0127–9696 E-ISSN 2180–3722 http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/6713 http://dx.doi.org/10.11113/jt.v77.6713 |
| repository_type |
Digital Repository |
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Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QK Botany SB Plant culture TP248.13 Biotechnology |
| spellingShingle |
QK Botany SB Plant culture TP248.13 Biotechnology Ahmad Raus, Raha Abdullah, Norhayati Ismail, Nurul Fakhriah Shahbuddin, Munira Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| description |
Sphathiphyllum cannifolium is abundantly planted in Malaysia as a landscape plant. However, this plant also has medical benefit to human as it was previously found to possess anti-bacteria and anti-cancer activities. In the present study, the plant was evaluated for its anti inflammatory activity and the optimum condition for the extraction of bioactive compounds with anti inflammatory activity was determined. Semi purification of the compounds possessing anti inflammatory activity was conducted as well. To extract the bioactive compound, sonication with methanol as a solvent extraction was carried out. Face-Centered Central Composite Design (FCCCD) and Response Surface Methodology (RSM) were used to design and identify the optimum condition to extract the compound, respectively. The results showed that the plant was positive for the anti inflammatory activity with IC50 6.3 µg/ml. Sonication for 60 min at 40°C using medium frequency was the optimum condition to carry out the extraction for bioactive compounds. After semi purification of the initial crude extract by solvent partitioning, chloroform fraction was found to be positive for anti inflammatory activity. In conclusion, this study suggested that S. cannifolium possess anti inflammatory activity and should be further analyzed to identify the specific compounds that responsible for this activity. |
| format |
Article |
| author |
Ahmad Raus, Raha Abdullah, Norhayati Ismail, Nurul Fakhriah Shahbuddin, Munira |
| author_facet |
Ahmad Raus, Raha Abdullah, Norhayati Ismail, Nurul Fakhriah Shahbuddin, Munira |
| author_sort |
Ahmad Raus, Raha |
| title |
Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| title_short |
Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| title_full |
Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| title_fullStr |
Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| title_full_unstemmed |
Extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| title_sort |
extraction and evaluation of anti inflammatory activity of spathiphyllum cannifolium |
| publisher |
Universiti Teknologi Malaysia |
| publishDate |
2015 |
| url |
http://irep.iium.edu.my/47430/ http://irep.iium.edu.my/47430/ http://irep.iium.edu.my/47430/ http://irep.iium.edu.my/47430/1/6713-18450-1-SM.pdf |
| first_indexed |
2023-09-18T21:07:30Z |
| last_indexed |
2023-09-18T21:07:30Z |
| _version_ |
1777411031209869312 |