Distribution pattern of hepatitis C virus in eastern peninsular Malaysia for the past decade
Introduction: Analysis of the Hepatitis C Virus (HCV) genotype spread in a particular area has a crucial impact on public health. Genotyping is essential before initiating treatment. Methods: This is a hospital-based cohort of 133 chronic hepatitis C patients, collected prospectively among subje...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley Publishing Asia Pty Ltd
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/47476/ http://irep.iium.edu.my/47476/ http://irep.iium.edu.my/47476/2/2015-Journal_of_Gastroenterology_and_Hepatology.pdf |
| Summary: | Introduction: Analysis of the Hepatitis C Virus (HCV) genotype spread in a particular area has a crucial impact on public health. Genotyping is essential before initiating treatment.
Methods: This is a hospital-based cohort of 133 chronic hepatitis C patients, collected prospectively among subjects attending Hospital Tengku Ampuan Afzan, Kuantan, within an area of eastern Peninsular Malaysia. We assessed the rate and distribution of HCV genotypes during two consecutive periods, from 2005 to 2006 and from 2013 to 2014, according to age, gender, race and risk factors.
Results: Genotypes 3 and 1 were predominant followed by genotype 4 and 6. Statistical evaluation of the demographic of HCV patients stratified by genotypes did not revealed any significant difference between the two periods. There was no association between the risk factors analyzed and the acquisition of different HCV genotypes. However, there was significant difference for the treatment received in the second cohort (p<0.005).
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