Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for ev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf |
| Summary: | Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this
study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase
NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating
kidney damage.
Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study.
Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by
spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the
government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.
Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in
patients compared to control group. Compared with control subjects, activities and specific activities of
serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01).
Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3
SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients
with nephrolithiasis. |
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