Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals

Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for ev...

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Main Authors:	Yusof, Faridah, Mehde, Atheer Awad, Mehdi, Wesen Adel, Ahmad Raus, Raha, Ghazali, Hamid, Abdul Rahman, Azlina
Format:	Article
Language:	English
Published:	Elsevier 2015
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf

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spelling	iium-478082018-05-23T01:57:51Z http://irep.iium.edu.my/47808/ Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina R Medicine (General) Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01). Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis. Elsevier 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf Yusof, Faridah and Mehde, Atheer Awad and Mehdi, Wesen Adel and Ahmad Raus, Raha and Ghazali, Hamid and Abdul Rahman, Azlina (2015) Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals. Biomedical and Environmental Science, 28 (9). pp. 660-665. ISSN 0895-3988 http://www.journals.elsevier.com/biomedical-and-environmental-sciences/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
description	Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01). Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.
format	Article
author	Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina
author_facet	Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina
author_sort	Yusof, Faridah
title	Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
title_short	Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
title_full	Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
title_fullStr	Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
title_full_unstemmed	Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
title_sort	effects of nephrolithiasis on serum dnase (deoxyribonuclease i and ii) activity and e3 sumo-protein ligase nse2 (nsmce2) in malaysian individuals
publisher	Elsevier
publishDate	2015
url	http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf
first_indexed	2023-09-18T21:07:58Z
last_indexed	2023-09-18T21:07:58Z
_version_	1777411061308194816

Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals

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