Scaling-up recombinant enzyme fermentation

Scaling-up recombinant enzyme fermentation

Bioreactor or fermenter is the heart of a process. Scaling up a bioreactor and maintaining the same optimized process in a recombinant enzyme production in a higher scale is an engineering challenge. Scale-up is about mixing and mass transfer, a combination of art and science. It is more to methodol...

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Main Authors: Azmi, Azlin Suhaida, Sulaiman, Sarina, Mohamed Azmin, Nor Fadhillah, Ali, Fathilah
Other Authors: Amid, Azura
Format: Book Chapter
Language:English
Published: Springer International Publishing 2015
Subjects:
TA164 Bioengineering
Online Access:http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/8/One-Kenobi.pdf
id iium-47856
recordtype eprints
spelling iium-478562016-07-19T13:09:52Z http://irep.iium.edu.my/47856/ Scaling-up recombinant enzyme fermentation Azmi, Azlin Suhaida Sulaiman, Sarina Mohamed Azmin, Nor Fadhillah Ali, Fathilah TA164 Bioengineering Bioreactor or fermenter is the heart of a process. Scaling up a bioreactor and maintaining the same optimized process in a recombinant enzyme production in a higher scale is an engineering challenge. Scale-up is about mixing and mass transfer, a combination of art and science. It is more to methodological approach with some combination of rules of thumb, experience and/or trial and error. This chapter presented several bioreactor or fermenter modes and types before encompasses four different scale-up strategies. The scale-up strategies related to mass transfer involving constants scale-up of; (i)volumetric transfer coefficient (KLa), (ii) power input per liquid volume (P/V), (iii) impeller tip speed (Vi), and (iv) mixing time (t m) are described and discussed. Springer International Publishing Amid, Azura 2015 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/47856/8/One-Kenobi.pdf Azmi, Azlin Suhaida and Sulaiman, Sarina and Mohamed Azmin, Nor Fadhillah and Ali, Fathilah (2015) Scaling-up recombinant enzyme fermentation. In: Recombinant Enzymes - From Basic Science to Commercialization. Springer International Publishing, Springer International Publishing Switzerland, pp. 99-113. ISBN 978-3-319-12397-4 http://link.springer.com/chapter/10.1007%2F978-3-319-12397-4_7 10.1007/978-3-319-12397-4_7
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic TA164 Bioengineering
spellingShingle TA164 Bioengineering
Azmi, Azlin Suhaida
Sulaiman, Sarina
Mohamed Azmin, Nor Fadhillah
Ali, Fathilah
Scaling-up recombinant enzyme fermentation
description Bioreactor or fermenter is the heart of a process. Scaling up a bioreactor and maintaining the same optimized process in a recombinant enzyme production in a higher scale is an engineering challenge. Scale-up is about mixing and mass transfer, a combination of art and science. It is more to methodological approach with some combination of rules of thumb, experience and/or trial and error. This chapter presented several bioreactor or fermenter modes and types before encompasses four different scale-up strategies. The scale-up strategies related to mass transfer involving constants scale-up of; (i)volumetric transfer coefficient (KLa), (ii) power input per liquid volume (P/V), (iii) impeller tip speed (Vi), and (iv) mixing time (t m) are described and discussed.
author2 Amid, Azura
author_facet Amid, Azura
Azmi, Azlin Suhaida
Sulaiman, Sarina
Mohamed Azmin, Nor Fadhillah
Ali, Fathilah
format Book Chapter
author Azmi, Azlin Suhaida
Sulaiman, Sarina
Mohamed Azmin, Nor Fadhillah
Ali, Fathilah
author_sort Azmi, Azlin Suhaida
title Scaling-up recombinant enzyme fermentation
title_short Scaling-up recombinant enzyme fermentation
title_full Scaling-up recombinant enzyme fermentation
title_fullStr Scaling-up recombinant enzyme fermentation
title_full_unstemmed Scaling-up recombinant enzyme fermentation
title_sort scaling-up recombinant enzyme fermentation
publisher Springer International Publishing
publishDate 2015
url http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/
http://irep.iium.edu.my/47856/8/One-Kenobi.pdf
first_indexed 2023-09-18T21:08:03Z
last_indexed 2023-09-18T21:08:03Z
_version_ 1777411066393788416

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