Clozapine re-challenge with lithium supplementation following clozapine-induced neutropenia
Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvem...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
ASEAN Federation of Psychiatry
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/ http://irep.iium.edu.my/47979/1/CLOZAPINE_RE-CHALLENGE_WITH_LITHIUM.pdf |
| Summary: | Objectives: This paper aims to report on a case in which re-challenging with
clozapine in combination with lithium in a patient who developed neutropenia
was carried out. Methods: The patient was treated with clozapine for treatmentresistant
schizophrenia. After five weeks he showed much improvement but
developed neutropenia. Withdrawal of clozapine brought on a relapse of
psychotic symptoms. Subsequently, clozapine was reintroduced along with
Lithium. The neutrophil count was monitored closely. Results: The neutrophil
and white blood cell count were noted to return to normal upon re-challenging,
and the patient’s clinical condition also improved. Conclusion: Simultaneous
administration of lithium and clozapine to patients experiencing neutropenia on
clozapine is a possible strategy. However, very close monitoring of the white
count is needed
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