The use of Oral Bovril as growth hormone stimulation test
Introduction: The gold standard for diagnosing growth hormone deficiency is insulin tolerance test. However, this is contraindicated in patients at risk of seizure attacks. GHRH-arginine test is not widely available. The other tests have their own limitations. Oral Bovril contains arginine and ca...
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Malaysian Endocrine & Metabolic Society
2014
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| Online Access: | http://irep.iium.edu.my/48182/ http://irep.iium.edu.my/48182/ http://irep.iium.edu.my/48182/6/PP-040.pdf |
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iium-481822018-06-12T03:03:05Z http://irep.iium.edu.my/48182/ The use of Oral Bovril as growth hormone stimulation test Loh, Huai Heng S , Norlela Abd Wahab, Norasyikin M, Norlaila O, Mohd Rahman R, Subashini Shahar, Mohammad Arif Omar, Ahmad Marzuki WS, Wan Juani M., Azura Dina Ooi, CP S, Muhammad A, Mohan MT, Alif Adlan Kamaruddin, Nor Azmi RC Internal medicine Introduction: The gold standard for diagnosing growth hormone deficiency is insulin tolerance test. However, this is contraindicated in patients at risk of seizure attacks. GHRH-arginine test is not widely available. The other tests have their own limitations. Oral Bovril contains arginine and can be used as a substitute when all others are not available. Case: A 16-year old boy with underlying mitochondrial disease, complicated with myoclonus and secondary hypogonadism, presented with short stature. Oral Bovril test was performed to rule out growth hormone deficiency as other tests were not available. Materials and Methods: Oral Bovril, given as 14g/m2 body surface area, was used in this patient (subject A) after an overnight fast. The test was also performed on a healthy sex-matched adult (subject B) and a sex and age-matched patient with confirmed growth hormone deficiency (subject C). Serial blood tests were taken at baseline and half hourly for 2.5 hours. Results: Subject A attained peak growth hormone of 28.4mIU/L which was consistent with a normal response, hence ruling out growth hormone deficiency. Subject B attained peak growth hormone of 42.0mIU/L. Subject C has suppressed growth hormone throughout the test, consistent with previous insulin tolerance test. Conclusion: Oral Bovril test is an option when all other growth hormone stimulation tests cannot be performed. It is cheap, readily available, has no side effects, does not require intravenous infusion, and has fairly good performance. Malaysian Endocrine & Metabolic Society 2014-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48182/6/PP-040.pdf Loh, Huai Heng and S , Norlela and Abd Wahab, Norasyikin and M, Norlaila and O, Mohd Rahman and R, Subashini and Shahar, Mohammad Arif and Omar, Ahmad Marzuki and WS, Wan Juani and M., Azura Dina and Ooi, CP and S, Muhammad and A, Mohan and MT, Alif Adlan and Kamaruddin, Nor Azmi (2014) The use of Oral Bovril as growth hormone stimulation test. Journal of Endocrinology and Metabolism, 4 (1(Sup)). p. 28. ISSN 2229-9572 http://www.jmems.org/index.php/jmems/issue/view/5 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RC Internal medicine |
| spellingShingle |
RC Internal medicine Loh, Huai Heng S , Norlela Abd Wahab, Norasyikin M, Norlaila O, Mohd Rahman R, Subashini Shahar, Mohammad Arif Omar, Ahmad Marzuki WS, Wan Juani M., Azura Dina Ooi, CP S, Muhammad A, Mohan MT, Alif Adlan Kamaruddin, Nor Azmi The use of Oral Bovril as growth hormone stimulation test |
| description |
Introduction: The gold standard for diagnosing growth hormone deficiency
is insulin tolerance test. However, this is contraindicated in patients at risk of
seizure attacks. GHRH-arginine test is not widely available. The other tests
have their own limitations. Oral Bovril contains arginine and can be used as
a substitute when all others are not available.
Case: A 16-year old boy with underlying mitochondrial disease,
complicated with myoclonus and secondary hypogonadism, presented
with short stature. Oral Bovril test was performed to rule out growth
hormone deficiency as other tests were not available.
Materials and Methods: Oral Bovril, given as 14g/m2 body surface area,
was used in this patient (subject A) after an overnight fast. The test was
also performed on a healthy sex-matched adult (subject B) and a sex and
age-matched patient with confirmed growth hormone deficiency (subject
C). Serial blood tests were taken at baseline and half hourly for 2.5 hours.
Results: Subject A attained peak growth hormone of 28.4mIU/L which
was consistent with a normal response, hence ruling out growth hormone
deficiency. Subject B attained peak growth hormone of 42.0mIU/L. Subject
C has suppressed growth hormone throughout the test, consistent with
previous insulin tolerance test.
Conclusion: Oral Bovril test is an option when all other growth hormone
stimulation tests cannot be performed. It is cheap, readily available, has
no side effects, does not require intravenous infusion, and has fairly good
performance. |
| format |
Article |
| author |
Loh, Huai Heng S , Norlela Abd Wahab, Norasyikin M, Norlaila O, Mohd Rahman R, Subashini Shahar, Mohammad Arif Omar, Ahmad Marzuki WS, Wan Juani M., Azura Dina Ooi, CP S, Muhammad A, Mohan MT, Alif Adlan Kamaruddin, Nor Azmi |
| author_facet |
Loh, Huai Heng S , Norlela Abd Wahab, Norasyikin M, Norlaila O, Mohd Rahman R, Subashini Shahar, Mohammad Arif Omar, Ahmad Marzuki WS, Wan Juani M., Azura Dina Ooi, CP S, Muhammad A, Mohan MT, Alif Adlan Kamaruddin, Nor Azmi |
| author_sort |
Loh, Huai Heng |
| title |
The use of Oral Bovril as growth hormone stimulation test |
| title_short |
The use of Oral Bovril as growth hormone stimulation test |
| title_full |
The use of Oral Bovril as growth hormone stimulation test |
| title_fullStr |
The use of Oral Bovril as growth hormone stimulation test |
| title_full_unstemmed |
The use of Oral Bovril as growth hormone stimulation test |
| title_sort |
use of oral bovril as growth hormone stimulation test |
| publisher |
Malaysian Endocrine & Metabolic Society |
| publishDate |
2014 |
| url |
http://irep.iium.edu.my/48182/ http://irep.iium.edu.my/48182/ http://irep.iium.edu.my/48182/6/PP-040.pdf |
| first_indexed |
2023-09-18T21:08:24Z |
| last_indexed |
2023-09-18T21:08:24Z |
| _version_ |
1777411088374038528 |