Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure

Human worldwide are exposed to arsenic mainly through drinking of arsenic-contaminated ground water. Arsenic is one of the environmental toxins reported to be associated with atherosclerosis with more attention given to inorganic arsenic as it was thought to be more toxic. Since organic arsenic part...

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Main Authors:	Abdullah, Nor Zamzila, Ishola, Afeez Adekunle, A.Talib, Norlelawati, Muhammad, Naznin, Buyong, Zunariah, Myint, Yi Yi, Mohamed, Abdul Hadi, Samsuddin, Niza, Abdul Ghani, Radiah
Format:	Article
Language:	English
Published:	College of Pathologists, Academy of Medicine Malaysia 2015
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/48382/ http://irep.iium.edu.my/48382/1/Malaysian_Journal_of_PathologyAugust__2015.pdf

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recordtype	eprints
spelling	iium-483822016-07-19T06:16:34Z http://irep.iium.edu.my/48382/ Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure Abdullah, Nor Zamzila Ishola, Afeez Adekunle A.Talib, Norlelawati Muhammad, Naznin Buyong, Zunariah Myint, Yi Yi Mohamed, Abdul Hadi Samsuddin, Niza Abdul Ghani, Radiah RB Pathology Human worldwide are exposed to arsenic mainly through drinking of arsenic-contaminated ground water. Arsenic is one of the environmental toxins reported to be associated with atherosclerosis with more attention given to inorganic arsenic as it was thought to be more toxic. Since organic arsenic particularly monosodium methylarsonate are still popularly being used and produced for agricultural activities, this study aimed to investigate the effects of chronic organic-arsenic exposure on the development of atherosclerosis in a rat model based on real human exposure. Materials & Methods: Fifty five male Sprague-Dawley rats were divided into 5 groups including a control group. Four treatment groups received oral intubation of monosodium-methylarsonate (MSMA) at 42.13, 63.30, 126.4 and 210.67 mg/kg body weight respectively every day for 16 weeks. Aorta were harvested and stained for H&E and Verhoef Van Gieson as well as for immunohistochemistry VCAM-1 and ICAM-1. Results: Rats treated with 126.4 and 210.67 mg/Kg BW of MSMA was noted to have high mortality due to severe diarrhea and drastic weight reduction and therefore was discontinued from our study. Rats treated with 42.13 and 63.3 mg/Kg BW MSMA showed positive early atherosclerosis changes microscopically with positive VCAM-1 and ICAM-1 expression. Discussion: This study highlighted that chronic organic arsenic exposure with MSMA also leads to the development of atherosclerosis. This indicates that chronic organic arsenic exposure is as equally toxic as inorganic arsenic exposure in the development of atherosclerosis. College of Pathologists, Academy of Medicine Malaysia 2015-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48382/1/Malaysian_Journal_of_PathologyAugust__2015.pdf Abdullah, Nor Zamzila and Ishola, Afeez Adekunle and A.Talib, Norlelawati and Muhammad, Naznin and Buyong, Zunariah and Myint, Yi Yi and Mohamed, Abdul Hadi and Samsuddin, Niza and Abdul Ghani, Radiah (2015) Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure. The Malaysian Journal of Pathology, 37 (2). p. 188. ISSN 0126-8635
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Abdullah, Nor Zamzila Ishola, Afeez Adekunle A.Talib, Norlelawati Muhammad, Naznin Buyong, Zunariah Myint, Yi Yi Mohamed, Abdul Hadi Samsuddin, Niza Abdul Ghani, Radiah Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
description	Human worldwide are exposed to arsenic mainly through drinking of arsenic-contaminated ground water. Arsenic is one of the environmental toxins reported to be associated with atherosclerosis with more attention given to inorganic arsenic as it was thought to be more toxic. Since organic arsenic particularly monosodium methylarsonate are still popularly being used and produced for agricultural activities, this study aimed to investigate the effects of chronic organic-arsenic exposure on the development of atherosclerosis in a rat model based on real human exposure. Materials & Methods: Fifty five male Sprague-Dawley rats were divided into 5 groups including a control group. Four treatment groups received oral intubation of monosodium-methylarsonate (MSMA) at 42.13, 63.30, 126.4 and 210.67 mg/kg body weight respectively every day for 16 weeks. Aorta were harvested and stained for H&E and Verhoef Van Gieson as well as for immunohistochemistry VCAM-1 and ICAM-1. Results: Rats treated with 126.4 and 210.67 mg/Kg BW of MSMA was noted to have high mortality due to severe diarrhea and drastic weight reduction and therefore was discontinued from our study. Rats treated with 42.13 and 63.3 mg/Kg BW MSMA showed positive early atherosclerosis changes microscopically with positive VCAM-1 and ICAM-1 expression. Discussion: This study highlighted that chronic organic arsenic exposure with MSMA also leads to the development of atherosclerosis. This indicates that chronic organic arsenic exposure is as equally toxic as inorganic arsenic exposure in the development of atherosclerosis.
format	Article
author	Abdullah, Nor Zamzila Ishola, Afeez Adekunle A.Talib, Norlelawati Muhammad, Naznin Buyong, Zunariah Myint, Yi Yi Mohamed, Abdul Hadi Samsuddin, Niza Abdul Ghani, Radiah
author_facet	Abdullah, Nor Zamzila Ishola, Afeez Adekunle A.Talib, Norlelawati Muhammad, Naznin Buyong, Zunariah Myint, Yi Yi Mohamed, Abdul Hadi Samsuddin, Niza Abdul Ghani, Radiah
author_sort	Abdullah, Nor Zamzila
title	Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
title_short	Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
title_full	Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
title_fullStr	Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
title_full_unstemmed	Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
title_sort	atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure
publisher	College of Pathologists, Academy of Medicine Malaysia
publishDate	2015
url	http://irep.iium.edu.my/48382/ http://irep.iium.edu.my/48382/1/Malaysian_Journal_of_PathologyAugust__2015.pdf
first_indexed	2023-09-18T21:08:38Z
last_indexed	2023-09-18T21:08:38Z
_version_	1777411103177834496

Atherosclerosis in chronic organic arsenic (monosodium methylarsonate) exposure

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