Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development

Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development

Monosodium methylarsonate (MSMA) is a potent organoarsenical used as herbicides in many countries. Human are particularly exposed by drinking of contaminated water. Epidemiological studies have linked high chronic arsenic exposure with cardiovascular diseases but the mechanism is not clear. Studies...

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Main Authors: Adekunle, Ishola Afeez, Abdullah, Nor Zamzila, A.Talib, Norlelawati, Muhammad, Naznin, Buyong, Zunariah, Myint, Yi Yi, Mohamed, Abdul Hadi, Samsuddin, Niza, Abdul Ghani, Radiah
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/48389/
http://irep.iium.edu.my/48389/
http://irep.iium.edu.my/48389/1/48389_abstract.pdf
id iium-48389
recordtype eprints
spelling iium-483892016-02-04T06:02:57Z http://irep.iium.edu.my/48389/ Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development Adekunle, Ishola Afeez Abdullah, Nor Zamzila A.Talib, Norlelawati Muhammad, Naznin Buyong, Zunariah Myint, Yi Yi Mohamed, Abdul Hadi Samsuddin, Niza Abdul Ghani, Radiah RB Pathology Monosodium methylarsonate (MSMA) is a potent organoarsenical used as herbicides in many countries. Human are particularly exposed by drinking of contaminated water. Epidemiological studies have linked high chronic arsenic exposure with cardiovascular diseases but the mechanism is not clear. Studies investigating the effects of MSMA are scarce as previous studies are focusing more on the effects of inorganic arsenic. Hence, this study aimed to investigate the effects of oral MSMA on atherosclerosis development in rats through its effects of PON1 enzyme and oxidized-LDL (Ox-LDL). Materials & Methods: Twenty-four male Sprague-Dawley rats were divided into three groups (n=8) including a control group. Treatment groups 1 and 2 were given oral MSMA of 42.13 and 63.30 mg/kg body weight respectively every day for 120 days. Serum PON1 activities and Ox-LDL level were measured. Aorta were microscopically evaluated after staining with Haematoxylin and Eosin (H&E), Verhoef Van Gieson (VVG) as well as with immunohistochemistry VCAM-1 and ICAM-1. Results: Our results revealed a significantly (p<0.05) higher Ox-LDL level and lower PON1: Ox-LDL ratio among the MSMA treated groups as compared to that of control group. Both MSMA treated groups also showed positive early atherosclerosis changes microscopically with positive VCAM-1 and ICAM-1 expression. Conclusions: The study highlighted that Chronic MSMA exposure affects the PON-1 activities and promotes LDL oxidation. The development of early atherosclerosis seen in chronic MSMA exposure may be explained by inability of PON1 to hydrolyze Ox-LDL. 2015-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/48389/1/48389_abstract.pdf Adekunle, Ishola Afeez and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Muhammad, Naznin and Buyong, Zunariah and Myint, Yi Yi and Mohamed, Abdul Hadi and Samsuddin, Niza and Abdul Ghani, Radiah (2015) Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development. In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’, 10th-12th August 2015, Impiana Resort Cherating, Pahang, Malaysia. (Unpublished) http://www.iium.edu.my/icast/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RB Pathology
spellingShingle RB Pathology
Adekunle, Ishola Afeez
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Muhammad, Naznin
Buyong, Zunariah
Myint, Yi Yi
Mohamed, Abdul Hadi
Samsuddin, Niza
Abdul Ghani, Radiah
Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
description Monosodium methylarsonate (MSMA) is a potent organoarsenical used as herbicides in many countries. Human are particularly exposed by drinking of contaminated water. Epidemiological studies have linked high chronic arsenic exposure with cardiovascular diseases but the mechanism is not clear. Studies investigating the effects of MSMA are scarce as previous studies are focusing more on the effects of inorganic arsenic. Hence, this study aimed to investigate the effects of oral MSMA on atherosclerosis development in rats through its effects of PON1 enzyme and oxidized-LDL (Ox-LDL). Materials & Methods: Twenty-four male Sprague-Dawley rats were divided into three groups (n=8) including a control group. Treatment groups 1 and 2 were given oral MSMA of 42.13 and 63.30 mg/kg body weight respectively every day for 120 days. Serum PON1 activities and Ox-LDL level were measured. Aorta were microscopically evaluated after staining with Haematoxylin and Eosin (H&E), Verhoef Van Gieson (VVG) as well as with immunohistochemistry VCAM-1 and ICAM-1. Results: Our results revealed a significantly (p<0.05) higher Ox-LDL level and lower PON1: Ox-LDL ratio among the MSMA treated groups as compared to that of control group. Both MSMA treated groups also showed positive early atherosclerosis changes microscopically with positive VCAM-1 and ICAM-1 expression. Conclusions: The study highlighted that Chronic MSMA exposure affects the PON-1 activities and promotes LDL oxidation. The development of early atherosclerosis seen in chronic MSMA exposure may be explained by inability of PON1 to hydrolyze Ox-LDL.
format Conference or Workshop Item
author Adekunle, Ishola Afeez
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Muhammad, Naznin
Buyong, Zunariah
Myint, Yi Yi
Mohamed, Abdul Hadi
Samsuddin, Niza
Abdul Ghani, Radiah
author_facet Adekunle, Ishola Afeez
Abdullah, Nor Zamzila
A.Talib, Norlelawati
Muhammad, Naznin
Buyong, Zunariah
Myint, Yi Yi
Mohamed, Abdul Hadi
Samsuddin, Niza
Abdul Ghani, Radiah
author_sort Adekunle, Ishola Afeez
title Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
title_short Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
title_full Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
title_fullStr Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
title_full_unstemmed Chronic Monosodium Methylarsonate (MSMA) exposure induces oxidation of Low Density Lipoprotein (LDL) and early atherosclerosis development
title_sort chronic monosodium methylarsonate (msma) exposure induces oxidation of low density lipoprotein (ldl) and early atherosclerosis development
publishDate 2015
url http://irep.iium.edu.my/48389/
http://irep.iium.edu.my/48389/
http://irep.iium.edu.my/48389/1/48389_abstract.pdf
first_indexed 2023-09-18T21:08:39Z
last_indexed 2023-09-18T21:08:39Z
_version_ 1777411103898206208

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