Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum

Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities ag...

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Main Authors:	Aminudin, Nurul Iman, Ahmad, Farediah, Bakhtiar, M. Taher, Mohamed Zulkifli, Rezauden
Format:	Article
Language:	English English
Published:	Journal of Applied Pharmaceutical Science 2016
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf

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recordtype	eprints
spelling	iium-495652016-12-22T00:16:40Z http://irep.iium.edu.my/49565/ Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden RS Pharmacy and materia medica Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 μg/mL and A-549 at 26.41μg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125μg/mL and 62.5μg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals Journal of Applied Pharmaceutical Science 2016-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf application/pdf en http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Rezauden (2016) Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum. Journal of Applied Pharmaceutical Science, 6 (1). pp. 23-27. ISSN 2231-3354 http://www.japsonline.com/admin/php/uploads/1743_pdf.pdf 10.7324/JAPS.2016.600104
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
description	Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 μg/mL and A-549 at 26.41μg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125μg/mL and 62.5μg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals
format	Article
author	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden
author_facet	Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden
author_sort	Aminudin, Nurul Iman
title	Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
title_short	Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
title_full	Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
title_fullStr	Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
title_full_unstemmed	Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
title_sort	cytotoxic and antibacterial evaluation of coumarins and chromanone acid from calophyllum symingtonianum
publisher	Journal of Applied Pharmaceutical Science
publishDate	2016
url	http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf
first_indexed	2023-09-18T21:10:04Z
last_indexed	2023-09-18T21:10:04Z
_version_	1777411192740904960

Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum

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